Anti-TIRAP (phospho Y86)抗体(ab111509)

概述

  • 产品名称Anti-TIRAP (phospho Y86)抗体
    参阅全部 TIRAP 一抗
  • 描述
    兔多克隆抗体to TIRAP (phospho Y86)
  • 特异性ab111509 detects endogenous levels of TIRAP only when phosphorylated at tyrosine 86 (Human: Tyr86; Mouse: Tyr106).
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic phosphopeptide derived from Human TIRAP around the phosphorylation site of tyrosine 86 (K-D-YP-D-V).

  • 阳性对照
    • Human brain tissue

性能

应用

Our Abpromise guarantee covers the use of ab111509 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 相关性The Toll-like receptor (TLR) family in mammals comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. TIRAP (TIR domain-containing adaptor protein) is an adaptor protein used by TLR4. Blocking TIRAP inhibits TLR4-mediated signaling events, including DC maturation and cytokine production. Function: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. Tissue specificity: Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain. Post-translational modification: Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK. Sequence similarities: Contains 1 TIR domain.
  • 细胞定位Cytoplasmic
  • 数据库链接
  • 别名
    • Adapter protein wyatt antibody
    • FLJ42305 antibody
    • MAL antibody
    • MyD88 adapter like protein antibody
    • TIR domain containing adapter protein antibody
    • Toll interleukin 1 receptor (TIR) domain containing adaptor protein antibody
    • Toll interleukin 1 receptor domain containing adapter protein antibody
    • Toll like receptor adaptor protein antibody
    • Wyatt antibody
    see all

Anti-TIRAP (phospho Y86) antibody 图像

  • ab111509, at 1/50 dilution, staining TIRAP in paraffin-embedded Human brain tissue by Immunohistochemistry, in the presence (right panel) or absence (left panel) of immunising peptide.

Anti-TIRAP (phospho Y86) antibody (ab111509)参考文献

ab111509 has not yet been referenced specifically in any publications.

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