概述

  • 产品名称Anti-Tin2抗体
    参阅全部 Tin2 一抗
  • 描述
    兔多克隆抗体to Tin2
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 396-445 (SDEEENGQGE GKESLENYQK TKFDTLIPTL CEYLPPSGHG AIPVSSCDCR) of Human Tin2 (NP_001092744).

  • 阳性对照
    • MCF7 cell lysate.

性能

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应用

Our Abpromise guarantee covers the use of ab82998 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration.

Titre using peptide based assay: 1/1562500.

WB Use a concentration of 1 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 50 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly.
  • 组织特异性Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 疾病相关Defects in TINF2 are a cause of dyskeratosis congenita autosomal dominant (ADDKC) [MIM:127550]; also known as dyskeratosis congenita Scoggins type. ADDKC is a rare, progressive bone marrow failure syndrome characterized by the triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy.
    Defects in TINF2 are a cause of retinopathy exudative with bone marrow failure (ERBMF) [MIM:268130]; also known as Revesz syndrome. ERBMF is characterized by bilateral exudative retinopathy, bone marrow hypoplasia, nail dystrophy, fine hair, cerebellar hypoplasia, and growth retardation.
  • 结构域The TBM domain mediates interaction with TERF1.
  • 细胞定位Nucleus. Chromosome > telomere. Associated with telomeres.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AW552114 antibody
    • D14Wsu146e antibody
    • DKCA3 antibody
    • MGC94711 antibody
    • TERF 1 (TRF 1) interacting nuclear factor 2 antibody
    • TERF 1 interacting nuclear factor 2 antibody
    • TERF1 (TRF1) interacting nuclear factor 2 antibody
    • TERF1 interacting nuclear factor 2 antibody
    • TERF1-interacting nuclear factor 2 antibody
    • Tin 2 antibody
    • TIN2 antibody
    • TINF 2 antibody
    • Tinf2 antibody
    • TINF2_HUMAN antibody
    • TRF 1 interacting nuclear factor 2 antibody
    • TRF1 interacting nuclear factor 2 antibody
    • TRF1-interacting nuclear protein 2 antibody
    see all

Anti-Tin2 antibody 图像

  • Anti-Tin2 antibody (ab82998) at 1 µg/ml (in 5% skim milk / PBS buffer) + MCF7 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 50 kDa
    Observed band size : 50 kDa
    Additional bands at : 90 kDa. We are unsure as to the identity of these extra bands.

Anti-Tin2 antibody (ab82998)参考文献

ab82998 has not yet been referenced specifically in any publications.

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