概述

  • 产品名称Anti-TIMP3抗体
    参阅全部 TIMP3 一抗
  • 描述
    兔多克隆抗体to TIMP3
  • 经测试应用适用于: ICC/IF, IHC-P, IHC-Frmore details
  • 种属反应性
    与反应: Rabbit, Human, Baboon
  • 免疫原

    Synthetic peptide from the C-terminus region of the human TIMP-3.

  • 阳性对照
    • Breast carcinoma

性能

应用

Our Abpromise guarantee covers the use of ab2169 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF
IHC-P
IHC-Fr
  • 应用说明ICC/IF: Use at an assay dependent dilution (PMID 19324423).
    IHC-P: Use at an assay dependent concentration.
    IHC-Fr: Use at an assay dependent concentration.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
    • 疾病相关Defects in TIMP3 are the cause of Sorsby fundus dystrophy (SFD) [MIM:136900]. SFD is a rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6 months to 6 years.
    • 序列相似性Belongs to the protease inhibitor I35 (TIMP) family.
      Contains 1 NTR domain.
    • 细胞定位Secreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • 数据库链接
    • 别名
      • HSMRK222 antibody
      • K222 antibody
      • K222TA2 antibody
      • Metalloproteinase inhibitor 3 antibody
      • MIG 5 protein antibody
      • MIG5 protein antibody
      • Protein MIG 5 antibody
      • Protein MIG-5 antibody
      • SFD antibody
      • Sorsby fundus dystrophy pseudoinflammatory antibody
      • TIMP 3 antibody
      • TIMP metallopeptidase inhibitor 3 antibody
      • TIMP-3 antibody
      • TIMP3 antibody
      • TIMP3_HUMAN antibody
      • Tissue Inhibitor of Metalloproteinase 3 antibody
      • Tissue inhibitor of metalloproteinases 3 antibody
      • Tissue inhibitor of metalloproteinases3 antibody
      see all

    Anti-TIMP3 antibody (ab2169)参考文献

    This product has been referenced in:
    • Hurst LA  et al. Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment. J Neuroimmunol 210:108-12 (2009). ICC/IF ; Human . Read more (PubMed: 19324423) »
    • Sun X  et al. Molecular characterization of tumour heterogeneity and malignant mesothelioma cell differentiation by gene profiling. J Pathol 207:91-101 (2005). Read more (PubMed: 16007577) »

    See all 2 Publications for this product

    Product Wall

    Thank you for your enquiry. The immunogen sequence is proprietary and we have not determined the homology to mouse. We would suggest comparing the C-terminus regions of human and mouse TIMP3. Please contact us again if you have any additional questi...

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    Thank you for your enquiry. For ab11814 I regret to inform you that the antibody has not yet been tested for application in IHC. The antibody has only so far been characterized for application in Western blotting and I have updated the online datasheet...

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    I'm sorry to hear you are having a problem with aab2169 in WB. We have not tested this antibody in western blotting and it is possible that the antibody does not work in this application, or that it requires the protein to be in its native form. I wou...

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    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application Immunohistochemistry (Frozen sections)
    Sample Human Tissue lysate - whole (Adult human skin)
    Specification Adult human skin
    Fixative Methanol
    Blocking step Serum as blocking agent for 20 minute(s) · Concentration: .02
    Username

    Abcam user community

    Verified customer

    提交于 Aug 26 2005

    Thank you for your enquiry and for your patience. Regarding ab2169, it has not been tested for cross-reactivity with TIPM 1,2 or 3. However, we would be more than happy to provide you the peptide sequence for you to see if there is any homology with TI...

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    We do not know its crossreactivity with mouse. However, it does not cross react with rat, cow, pig and bird. On the other hand, it does crossreact with rabbit and baboon.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"