Anti-TIMP1抗体[RM0136-6A34] (ab86482)

概述

  • 产品名称Anti-TIMP1抗体[RM0136-6A34]
    参阅全部 TIMP1 一抗
  • 描述
    大鼠单克隆抗体[RM0136-6A34] to TIMP1
  • 经测试应用适用于: IHC-Fr, WBmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Recombinant full length Mouse protein

性能

应用

Our Abpromise guarantee covers the use of ab86482 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr Use at an assay dependent concentration. PubMed: 21652631
WB 1/500 - 1/1000. Predicted molecular weight: 23 kDa.

靶标

  • 功能Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
  • 序列相似性Belongs to the protease inhibitor I35 (TIMP) family.
    Contains 1 NTR domain.
  • 翻译后修饰The activity of TIMP1 is dependent on the presence of disulfide bonds.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Clgi antibody
    • Collagenase inhibitor antibody
    • Collagenase inhibitor, Human antibody
    • EPA antibody
    • EPO antibody
    • Erythroid Potentiating Activity antibody
    • Erythroid-potentiating activity antibody
    • Fibroblast collagenase inhibitor antibody
    • FLJ90373 antibody
    • HCI antibody
    • Human Collagenase Inhibitor antibody
    • Metalloproteinase inhibitor 1 antibody
    • Metalloproteinase inhibitor 1 precursor antibody
    • OTTHUMP00000023214 antibody
    • TIMP 1 antibody
    • TIMP antibody
    • TIMP metallopeptidase inhibitor 1 antibody
    • TIMP-1 antibody
    • Timp1 antibody
    • TIMP1 protein antibody
    • TIMP1_HUMAN antibody
    • Tissue Inhibitor of Metalloproteinase 1 antibody
    • Tissue inhibitor of metalloproteinases 1 antibody
    • Tissue inhibitor of metalloproteinases antibody
    • Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor antibody
    see all

Anti-TIMP1 antibody [RM0136-6A34] (ab86482)参考文献

This product has been referenced in:
  • Delfín DA  et al. Cardiomyopathy in the dystrophin/utrophin-deficient mouse model of severe muscular dystrophy is characterized by dysregulation of matrix metalloproteinases. Neuromuscul Disord 22:1006-14 (2012). WB ; Mouse . Read more (PubMed: 22749475) »
  • Duarte S  et al. TIMP-1 deficiency leads to lethal partial hepatic ischemia and reperfusion injury. Hepatology 56:1074-85 (2012). IHC-Fr ; Mouse . Read more (PubMed: 22407827) »

See all 3 Publications for this product

Product Wall

As shown on the attached pdf, the homology between the human and the mouse TIMP1 proteins is only 72%. Furthermore, the epitope of ab1827 has not been determined and it is a Mouse monoclonal antibody, meaning that the staining in IHC will be Mouse on M...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"