概述

  • 产品名称Anti-TIMP1抗体[EPR1550]
    参阅全部 TIMP1 一抗
  • 描述
    兔单克隆抗体[EPR1550] to TIMP1
  • 经测试应用适用于: WB, IHC-Pmore details
    不适用于: Flow Cyt,ICC or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to residues in Human TIMP1.

  • 阳性对照
    • HL60+TPA, PBMC lysates; Human liver tissue; TIMP1 recombinant protein
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

应用

Our Abpromise guarantee covers the use of ab109125 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 23 kDa.
IHC-P 1/250 - 1/500.
  • 应用说明Is unsuitable for Flow Cyt,ICC or IP.
  • 靶标

    • 功能Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
    • 序列相似性Belongs to the protease inhibitor I35 (TIMP) family.
      Contains 1 NTR domain.
    • 翻译后修饰The activity of TIMP1 is dependent on the presence of disulfide bonds.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Clgi antibody
      • Collagenase inhibitor antibody
      • Collagenase inhibitor, Human antibody
      • EPA antibody
      • EPO antibody
      • Erythroid Potentiating Activity antibody
      • Erythroid-potentiating activity antibody
      • Fibroblast collagenase inhibitor antibody
      • FLJ90373 antibody
      • HCI antibody
      • Human Collagenase Inhibitor antibody
      • Metalloproteinase inhibitor 1 antibody
      • Metalloproteinase inhibitor 1 precursor antibody
      • OTTHUMP00000023214 antibody
      • TIMP 1 antibody
      • TIMP antibody
      • TIMP metallopeptidase inhibitor 1 antibody
      • TIMP-1 antibody
      • Timp1 antibody
      • TIMP1 protein antibody
      • TIMP1_HUMAN antibody
      • Tissue Inhibitor of Metalloproteinase 1 antibody
      • Tissue inhibitor of metalloproteinases 1 antibody
      • Tissue inhibitor of metalloproteinases antibody
      • Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor antibody
      see all

    Anti-TIMP1 antibody [EPR1550] 图像

    • ab109125, at 1/250 dilution staining TIMP1 in paraffin-embedded Human liver tissue, by Immunohistochemistry.
    • All lanes : Anti-TIMP1 antibody [EPR1550] (ab109125) at 1/1000 dilution

      Lane 1 : HL60+TPA cell lysates
      Lane 2 : PBMC cell lysates

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 23 kDa
    • Anti-TIMP1 antibody [EPR1550] (ab109125) at 1/1000 dilution + TIMP1 recombinant protein at 10 µg

      Predicted band size : 23 kDa

    Anti-TIMP1 antibody [EPR1550] (ab109125)参考文献

    This product has been referenced in:
    • Wang C  et al. Etoposide Induces Apoptosis in Activated Human Hepatic Stellate Cells via ER Stress. Sci Rep 6:34330 (2016). WB ; Human . Read more (PubMed: 27680712) »
    • Li T  et al. Effects of small interfering RNA-mediated downregulation of the Krüppel-like factor 4 gene on collagen metabolism in human hepatic stellate cells. Mol Med Rep 12:3972-8 (2015). Human . Read more (PubMed: 26018498) »

    See all 2 Publications for this product

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