概述

  • 产品名称
  • 描述
    小鼠单克隆抗体to TIMM9
  • 经测试应用
    适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein: MAAQIPESDQ IKQFKEFLGT YNKLTETCFL DCVKDFTTRE VKPEETTCSE HCLQKYLKMT QRISMRFQEY HIQQNEALAA KAGLLGQPR, corresponding to amino acids 1-90 of Human TIMM9

  • 常规说明

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.

性能

应用

Our Abpromise guarantee covers the use of ab57089 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明
    WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
    • 组织特异性
      Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.
    • 序列相似性
      Belongs to the small Tim family.
    • 结构域
      The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.
    • 细胞定位
      Mitochondrion inner membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Mitochondrial import inner membrane translocase subunit Tim9 antibody
      • TIM9 antibody
      • TIM9_HUMAN antibody
      • TIM9A antibody
      • Timm9 antibody
      • TIMM9A antibody
      see all

    图片

    • TIMM9 antibody (ab57089) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human small Intestine.


    • Predicted band size : 10 kDa
      TIMM9 antibody (ab57089) at 1ug/lane + IMR-32 cell lysate at 25ug/lane.

    文献

    This product has been referenced in:
    • Kang Y  et al. Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability. Elife 5:N/A (2016). Read more (PubMed: 27554484) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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