Anti-TIE1抗体(ab111547)

概述

  • 产品名称Anti-TIE1抗体
    参阅全部 TIE1 一抗
  • 描述
    兔多克隆抗体to TIE1
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 677 and 1021 (P35590) of TIE1

  • 阳性对照
    • A549 lysate, HeLa lysate

性能

应用

Our Abpromise guarantee covers the use of ab111547 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 125 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Alternative antigen retrieval method: Tris-EDTA buffer pH 8.0

靶标

  • 功能Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
  • 组织特异性Specifically expressed in developing vascular endothelial cells.
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
    Contains 3 EGF-like domains.
    Contains 3 fibronectin type-III domains.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • 翻译后修饰Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • JKT 14 antibody
    • JTK14 antibody
    • TIE antibody
    • Tie1 antibody
    • TIE1_HUMAN antibody
    • Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1 antibody
    • Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains antibody
    • Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 antibody
    • Tyrosine protein kinase receptor Tie 1 antibody
    • Tyrosine-protein kinase receptor Tie-1 antibody
    see all

Anti-TIE1 antibody 图像

  • Anti-TIE1 antibody (ab111547) at 1/1000 dilution + A549 lysate at 30 µg/ml

    Predicted band size : 125 kDa
  • Immunohistochemical analysis of paraffin embedded Colon carcinoma, using ab111547 at 1:500 dilution.

Anti-TIE1 antibody (ab111547)参考文献

ab111547 has not yet been referenced specifically in any publications.

Product Wall

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The immunogen for this product shares about 70% homology and so is not likely to react. Typically at about 85% there is likely reactivity.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"