Anti-TICAM2抗体(Alkaline Phosphatase) (ab26086)

概述

  • 产品名称Anti-TICAM2抗体(Alkaline Phosphatase)
    参阅全部 TICAM2 一抗
  • 描述
    兔多克隆抗体to TICAM2 (Alkaline Phosphatase)
  • 偶联物Alkaline Phosphatase
  • 特异性ab26086 recognises TICAM 2 protein.
  • 经测试应用适用于: ELISA, Dot blot, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide from the unique amino-terminal end of the protein, conjugated to KLH (peptide was post-synthetically modified to achieve highest antigenicty before used for coupling to KLH using heterobifunctional cross linker).

性能

应用

Our Abpromise guarantee covers the use of ab26086 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/20000.
Dot blot 1/20000.
WB 1/500 - 1/750. Predicted molecular weight: 27 kDa.

靶标

  • 功能Functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1.
  • 组织特异性Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas.
  • 序列相似性Contains 1 TIR domain.
  • 结构域The TIR domain mediates the interaction with TRAF6.
  • 翻译后修饰Phosphorylated by PKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.
    Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.
  • 细胞定位Cytoplasm. Golgi apparatus. Cell membrane. Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Putative NF-kappa-B-activating protein 502 antibody
    • TCAM2_HUMAN antibody
    • TICAM-2 antibody
    • TICAM2 antibody
    • TIR containing adapter molecule 2 antibody
    • TIR domain containing adaptor protein antibody
    • TIR domain-containing adapter molecule 2 antibody
    • TIRAP 3 antibody
    • TIRAP3 antibody
    • TIRAP3a short form antibody
    • TIRP antibody
    • Toll-like receptor adaptor protein 3 antibody
    • Toll/interleukin-1 receptor domain-containing protein antibody
    • TRAM antibody
    • TRIF-related adapter molecule antibody
    see all

Anti-TICAM2 antibody (Alkaline Phosphatase) (ab26086)参考文献

ab26086 has not yet been referenced specifically in any publications.

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