概述

  • 产品名称Anti-TIAM2抗体
    参阅全部 TIAM2 一抗
  • 描述
    小鼠单克隆抗体to TIAM2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: DVHPEAEQQP GPESGEGQKG GEQPKLVRGH FCPIKRKANS TKRDRGTLLK AQIRHQSLDS QSENATIDLN SVLEREFSVQ SLTSVVSEEC FYETESHG, corresponding to amino acids 527-625 of Human TIAM2

性能

应用

Our Abpromise guarantee covers the use of ab57033 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.
    • 组织特异性Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis.
    • 序列相似性Belongs to the TIAM family.
      Contains 1 DH (DBL-homology) domain.
      Contains 1 PDZ (DHR) domain.
      Contains 2 PH domains.
      Contains 1 RBD (Ras-binding) domain.
    • 结构域The PH 1 domain and amino acids 621-782 (a region called TSS; otherwise known as CC-Ex) are necessary for membrane localization. The PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce neurite-like structure.
    • 翻译后修饰Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1648 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth.
    • 细胞定位Cytoplasm. Cell projection > lamellipodium. Cell projection > filopodium. Cell projection > growth cone. Localizes to the plasma membrane in neurites.
    • Information by UniProt
    • 数据库链接
    • 别名
      • FLJ41865 antibody
      • OTTHUMP00000017472 antibody
      • SIF and TIAM1 like exchange factor antibody
      • SIF and TIAM1-like exchange factor antibody
      • STEF antibody
      • T cell lymphoma invasion and metastasis 2 antibody
      • T lymphoma invasion and metastasis inducing protein 2 antibody
      • T-lymphoma invasion and metastasis-inducing protein 2 antibody
      • TIAM 2 antibody
      • TIAM-2 antibody
      • Tiam2 antibody
      • TIAM2_HUMAN antibody
      see all

    Anti-TIAM2 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57033 TIAM2 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-TIAM2 antibody (ab57033)参考文献

    ab57033 has not yet been referenced specifically in any publications.

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