Anti-Thyroid Peroxidase/TPO抗体[MoAb47] (ab12500)
Key features and details
- Mouse monoclonal [MoAb47] to Thyroid Peroxidase/TPO
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-Thyroid Peroxidase/TPO抗体[MoAb47]
参阅全部 Thyroid Peroxidase/TPO 一抗 -
描述
小鼠单克隆抗体[MoAb47] to Thyroid Peroxidase/TPO -
宿主
Mouse -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Full length native protein (purified) corresponding to Human Thyroid Peroxidase/TPO.
Database link: P07202 -
阳性对照
- Thyroid
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.3
Preservative: 0.05% Sodium azide
Constituent: Tissue culture supernatant -
Concentration information loading...
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纯度
Tissue culture supernatant -
克隆
单克隆 -
克隆编号
MoAb47 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab12500于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P |
1/10 - 1/25. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Primary incubation for 30 min at room temperature. |
说明 |
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IHC-P
1/10 - 1/25. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. Primary incubation for 30 min at room temperature. |
靶标
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功能
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). -
通路
Hormone biosynthesis; thyroid hormone biosynthesis. -
疾病相关
Note=An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.
Defects in TPO are the cause of congenital hypothyroidism due to dyshormonogenesis type 2A (CHDH2A) [MIM:274500]; also called genetic defect in thyroid hormonogenesis 2A or thyroid hormone organification defect II. CHDH2A is due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. -
序列相似性
Belongs to the peroxidase family. XPO subfamily.
Contains 1 EGF-like domain.
Contains 1 Sushi (CCP/SCR) domain. -
翻译后修饰
Glycosylated.
Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
Cleaved in its N-terminal part. -
细胞定位
Membrane and Cell surface. - Information by UniProt
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数据库链接
- Entrez Gene: 7173 Human
- Omim: 606765 Human
- SwissProt: P07202 Human
- Unigene: 467554 Human
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别名
- MSA antibody
- PERT_HUMAN antibody
- TDH2A antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab12500 被引用在 3 文献中.
- Muller I et al. Does thyroid peroxidase provide an antigenic link between thyroid autoimmunity and breast cancer? Int J Cancer 134:1706-14 (2014). PubMed: 24114667
- Cairns DM et al. Muscle cells enhance resistance to pro-inflammatory cytokine-induced cartilage destruction. Biochem Biophys Res Commun 392:22-8 (2010). PubMed: 20043873
- Cairns DM et al. The role of muscle cells in regulating cartilage matrix production. J Orthop Res 28:529-36 (2010). PubMed: 19813241