RabMAb

Anti-Thyroid Peroxidase抗体[EPR5380] (ab109383)

概述

  • 产品名称Anti-Thyroid Peroxidase抗体[EPR5380]
    参阅全部 Thyroid Peroxidase 一抗
  • 描述
    兔单克隆抗体[EPR5380] to Thyroid Peroxidase
  • 经测试应用适用于: WB, IP, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A synthetic peptide corresponding to residues in the C terminal of Human Thyroid Peroxidase

  • 阳性对照
    • WB: Human thyroid lysate IHC-P: Human thyroid gland tissue
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

应用

Our Abpromise guarantee covers the use of ab109383 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 103 kDa.
IP 1/10 - 1/100.
IHC-P 1/100 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Heat up to 98 degrees C, below boiling, and then let cool for 10-20 min.

靶标

  • 功能Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
  • 通路Hormone biosynthesis; thyroid hormone biosynthesis.
  • 疾病相关Note=An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.
    Defects in TPO are the cause of congenital hypothyroidism due to dyshormonogenesis type 2A (CHDH2A) [MIM:274500]; also called genetic defect in thyroid hormonogenesis 2A or thyroid hormone organification defect II. CHDH2A is due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
  • 序列相似性Belongs to the peroxidase family. XPO subfamily.
    Contains 1 EGF-like domain.
    Contains 1 Sushi (CCP/SCR) domain.
  • 翻译后修饰Glycosylated.
    Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
    Cleaved in its N-terminal part.
  • 细胞定位Membrane and Cell surface.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MSA antibody
    • PERT_HUMAN antibody
    • TDH2A antibody
    • Thyroid microsomal antigen antibody
    • Thyroid peroxidase antibody
    • Thyroperoxidase antibody
    • TPO antibody
    • TPX antibody
    see all

Anti-Thyroid Peroxidase antibody [EPR5380] 图像

  • Anti-Thyroid Peroxidase antibody [EPR5380] (ab109383) at 1/1000 dilution + Human thyroid lysate at 10 µg

    Predicted band size : 103 kDa
  • ab109383, at a 1/100 dilution, staining Thyroid Peroxidase in paraffin-embedded Human thyroid gland tissue

Anti-Thyroid Peroxidase antibody [EPR5380] (ab109383)参考文献

ab109383 has not yet been referenced specifically in any publications.

Product Wall

Application IHC - Wholemount
Sample Human Tissue (Thyroid)
Specification Thyroid
Username

Miss. Juri Na

Verified customer

提交于 May 05 2014

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"