Anti-Thyroid Peroxidase抗体[1.B.10] (ab31829)

概述

  • 产品名称Anti-Thyroid Peroxidase抗体[1.B.10]
    参阅全部 Thyroid Peroxidase 一抗
  • 描述
    小鼠单克隆抗体[1.B.10] to Thyroid Peroxidase
  • 特异性Ab31829 recocgnises Thyroid Peroxidase.
  • 经测试应用适用于: ELISA, Immunoelectrophoresismore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein (Human).

性能

应用

Our Abpromise guarantee covers the use of ab31829 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use a concentration of 0.1 - 1 µg/ml.
Immunoelectrophoresis Use at an assay dependent dilution.
AP Use at an assay dependent dilution.

靶标

  • 功能Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
  • 通路Hormone biosynthesis; thyroid hormone biosynthesis.
  • 疾病相关Note=An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.
    Defects in TPO are the cause of congenital hypothyroidism due to dyshormonogenesis type 2A (CHDH2A) [MIM:274500]; also called genetic defect in thyroid hormonogenesis 2A or thyroid hormone organification defect II. CHDH2A is due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
  • 序列相似性Belongs to the peroxidase family. XPO subfamily.
    Contains 1 EGF-like domain.
    Contains 1 Sushi (CCP/SCR) domain.
  • 翻译后修饰Glycosylated.
    Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
    Cleaved in its N-terminal part.
  • 细胞定位Membrane and Cell surface.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MSA antibody
    • PERT_HUMAN antibody
    • TDH2A antibody
    • Thyroid microsomal antigen antibody
    • Thyroid peroxidase antibody
    • Thyroperoxidase antibody
    • TPO antibody
    • TPX antibody
    see all

Anti-Thyroid Peroxidase antibody [1.B.10] (ab31829)参考文献

ab31829 has not yet been referenced specifically in any publications.

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