Anti-Thyroid Hormone Receptor beta抗体- ChIP Grade (ab104417)

概述

  • 产品名称Anti-Thyroid Hormone Receptor beta抗体- ChIP Grade
    参阅全部 Thyroid Hormone Receptor beta 一抗
  • 描述
    兔多克隆抗体to Thyroid Hormone Receptor beta - ChIP Grade
  • 经测试应用适用于: ChIP, WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 1-50 (MNYCMPEVHE VCPAASSNCY MQVTDYLAYL EDSPALSGRD VQAVPSSSIY) of Mouse Thyroid Hormone (NP_033406; UniProt ID: P10828 isoform 2).

  • 阳性对照
    • Mouse muscle lysate

性能

应用

Our Abpromise guarantee covers the use of ab104417 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ChIP Use 10 µg for 100 µg of chromatin.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 2, 54 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能High affinity receptor for triiodothyronine.
  • 疾病相关Defects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
    Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also known as familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.
  • 序列相似性Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 结构域Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2 antibody
    • C ERBA 2 antibody
    • C ERBA BETA antibody
    • c-erbA-2 antibody
    • c-erbA-beta antibody
    • ERBA 2 antibody
    • ERBA BETA antibody
    • ERBA2 antibody
    • Erythroblastic leukemia viral (v erb a) oncogene homolog 2 avian antibody
    • generalized resistance to thyroid hormone antibody
    • GRTH antibody
    • MGC126109 antibody
    • MGC126110 antibody
    • NR1A2 antibody
    • Nuclear receptor subfamily 1 group A member 2 antibody
    • Oncogene ERBA2 antibody
    • PRTH antibody
    • THB_HUMAN antibody
    • THR1 antibody
    • THRB 1 antibody
    • THRB 2 antibody
    • thrB antibody
    • THRB1 antibody
    • THRB2 antibody
    • Thyroid hormone nuclear receptor beta variant 1 antibody
    • Thyroid hormone receptor beta 1 antibody
    • Thyroid hormone receptor beta 2 antibody
    • Thyroid hormone receptor beta antibody
    • Thyroid hormone receptor, beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2, avian) antibody
    see all

Anti-Thyroid Hormone Receptor beta antibody - ChIP Grade 图像

  • Anti-Thyroid Hormone Receptor beta antibody - ChIP Grade (ab104417) at 1 µg/ml + Mouse muscle lysate at 10 µg

    Predicted band size : 2, 54 kDa
  • Application: ChIP
    Sample Type
    : mouse liver tissue
    Chromatin Used: 100ug tissue
    Antibody Used: 10ug  
    P = Positive genomic loci 1-3

Anti-Thyroid Hormone Receptor beta antibody - ChIP Grade (ab104417)参考文献

ab104417 has not yet been referenced specifically in any publications.

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