Anti-Thyroid Hormone Receptor beta抗体(ab106813)

概述

  • 产品名称
    Anti-Thyroid Hormone Receptor beta抗体
    参阅全部 Thyroid Hormone Receptor beta 一抗
  • 描述
    山羊多克隆抗体to Thyroid Hormone Receptor beta
  • 特异性
    ab106813 is not expected to cross-react to THRA.
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Chicken, Dog, Pig
  • 免疫原

    Synthetic peptide:

    C-REELQKSIGHKP

    , corresponding to internal sequence amino acids 201-212 of Human Thyroid Hormone Receptor beta (NP_000452.2).

  • 阳性对照
    • Human Bone Marrow lysate

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab106813 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab106813 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: Isoform Beta 1, 53 ; Isoform Beta 2, 54 kDa.

靶标

  • 功能
    High affinity receptor for triiodothyronine.
  • 疾病相关
    Defects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
    Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also known as familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.
  • 序列相似性
    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 结构域
    Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2 antibody
    • C ERBA 2 antibody
    • C ERBA BETA antibody
    • c-erbA-2 antibody
    • c-erbA-beta antibody
    • ERBA 2 antibody
    • ERBA BETA antibody
    • ERBA2 antibody
    • Erythroblastic leukemia viral (v erb a) oncogene homolog 2 avian antibody
    • generalized resistance to thyroid hormone antibody
    • GRTH antibody
    • MGC126109 antibody
    • MGC126110 antibody
    • NR1A2 antibody
    • Nuclear receptor subfamily 1 group A member 2 antibody
    • Oncogene ERBA2 antibody
    • PRTH antibody
    • THB_HUMAN antibody
    • THR1 antibody
    • THRB 1 antibody
    • THRB 2 antibody
    • thrB antibody
    • THRB1 antibody
    • THRB2 antibody
    • Thyroid hormone nuclear receptor beta variant 1 antibody
    • Thyroid hormone receptor beta 1 antibody
    • Thyroid hormone receptor beta 2 antibody
    • Thyroid hormone receptor beta antibody
    • Thyroid hormone receptor, beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2, avian) antibody
    see all

图片

  • Anti-Thyroid Hormone Receptor beta antibody (ab106813) at 0.3 µg/ml + Human Bone Marrow lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : Isoform Beta 1, 53 ; Isoform Beta 2, 54 kDa

实验方案

文献

ab106813 has not yet been referenced specifically in any publications.

客户评价及客户问答

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