Anti-Thyroid Hormone Receptor alpha 1+2抗体(ab15543)

概述

  • 产品名称Anti-Thyroid Hormone Receptor alpha 1+2抗体
    参阅全部 Thyroid Hormone Receptor alpha 1+2 一抗
  • 描述
    兔多克隆抗体to Thyroid Hormone Receptor alpha 1+2
  • 特异性ab15543 reacts with both Thyroid Hormone Receptor alpha 1 and Thyroid Hormone Receptor alpha 2.
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Pig
  • 免疫原

    Synthetic peptide:

    GDETQWPNGVKRKRKNSQCS

    , corresponding to amino acids 13-32 of Human Thyroid Hormone Receptor alpha 1.

  • 阳性对照
    • Colon carcinoma.
  • 常规说明


    Thyroid receptors have expression patterns that vary according to tissue and developmental stage. Almost all tissues express the alpha-1, alpha-2 and beta-1 isoforms, but beta-2 is synthesized almost exclusively in hypothalamus, anterior pituitary and developing ear. Receptor alpha-1 is the first isoform expressed in the conceptus.

性能

应用

Our Abpromise guarantee covers the use of ab15543 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min.

靶标

  • 功能Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
    Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.
  • 疾病相关Hypothyroidism, congenital, non-goitrous, 6
  • 序列相似性Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 结构域Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • c-erbA-1 antibody
    • C-erbA-alpha antibody
    • EAR-7 antibody
    • ERBA 1 antibody
    • ERBA antibody
    • ERBA related 7 antibody
    • Nuclear receptor subfamily 1 group A member 1 antibody
    • THA_HUMAN antibody
    • THRA antibody
    • Thra1 antibody
    • Thra2 antibody
    • Thyroid hormone receptor alpha 1 antibody
    • Thyroid hormone receptor alpha 2 antibody
    • Thyroid hormone receptor alpha antibody
    • TR alpha 1 antibody
    • TR alpha 2 antibody
    • Tra1 antibody
    • Triiodothyronine receptor antibody
    • V-erbA-related protein 7 antibody
    see all

Anti-Thyroid Hormone Receptor alpha 1+2 antibody 图像

  • ab15543 staining Thyroid Hormone Receptor alpha 1 in colon carcinoma at 1/100 dilution by Immunohistochemistry (formalin/paraffin).

Anti-Thyroid Hormone Receptor alpha 1+2 antibody (ab15543)参考文献

ab15543 has not yet been referenced specifically in any publications.

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