Anti-Thyroglobulin抗体[SPM517], prediluted (ab52134)

概述

  • 产品名称Anti-Thyroglobulin抗体[SPM517], prediluted
    参阅全部 Thyroglobulin 一抗
  • 描述
    小鼠单克隆抗体[SPM517] to Thyroglobulin, prediluted
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human thyroglobulin

  • 阳性对照
    • Human thyroid tissue

性能

应用

Our Abpromise guarantee covers the use of ab52134 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: Ready-to-use for 30 min at RT. Staining of formalin-fixed tissues requires no pretreatment


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
    • 组织特异性Thyroid gland specific.
    • 疾病相关Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
      Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
    • 序列相似性Belongs to the type-B carboxylesterase/lipase family.
      Contains 11 thyroglobulin type-1 domains.
    • 翻译后修饰Sulfated tyrosines are desulfated during iodination.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AITD 3 antibody
      • AITD3 antibody
      • hTG antibody
      • TDH3 antibody
      • Tg antibody
      • TGN antibody
      • THYG_HUMAN antibody
      • Thyroglobulin antibody
      see all

    Anti-Thyroglobulin antibody [SPM517], prediluted 图像

    • ab52134, ready to use for staining human thyroglobulin in thyroid tissue using Immunohistochemsitry, Formalin fixed Paraffin embedded tissue.

    Anti-Thyroglobulin antibody [SPM517], prediluted (ab52134)参考文献

    ab52134 has not yet been referenced specifically in any publications.

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