The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500000 - 1/1e+006. Detects a band of approximately 300, 294 kDa (predicted molecular weight: 305 kDa).
应用说明Is unsuitable for Flow Cyt,ICC or IHC-P.
功能Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
组织特异性Thyroid gland specific.
疾病相关Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
序列相似性Belongs to the type-B carboxylesterase/lipase family. Contains 11 thyroglobulin type-1 domains.
翻译后修饰Sulfated tyrosines are desulfated during iodination.