Anti-Thyroglobulin抗体[EPR3614] (ab92467)

概述

• 产品名称
  Anti-Thyroglobulin抗体[EPR3614]
  参阅全部 Thyroglobulin 一抗
• 描述
  兔单克隆抗体[EPR3614] to Thyroglobulin
• 经测试应用
  适用于: WB, IP, IHC-P, ICC/IFmore details
• 种属反应性
  与反应: Human
  
• 免疫原

  A synthetic peptide corresponding to residues within Human Thyroglobulin.

• 阳性对照
  • WB: Human thyroid lysate IHC-P: Human papillary thyroid carcinoma
• 常规说明

  This product is a recombinant rabbit monoclonal antibody.

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• 存储溶液
  PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• 纯度
  Tissue culture supernatant
• 克隆
  单克隆
• 克隆编号
  EPR3614
• 同种型
  IgG
• 研究领域
  • Signal Transduction
  • Growth Factors/Hormones
  • Hormones

  • Cancer
  • Tumor biomarkers
  • Globulins

应用

靶标

• 功能
  Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
• 组织特异性
  Thyroid gland specific.
• 疾病相关
  Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
  Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
• 序列相似性
  Belongs to the type-B carboxylesterase/lipase family.
  Contains 11 thyroglobulin type-1 domains.
• 翻译后修饰
  Sulfated tyrosines are desulfated during iodination.
• 细胞定位
  Secreted.

• Target information above from: UniProt accession P01266 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 7038 Human
  • Omim: 188450 Human
  • SwissProt: P01266 Human
  • Unigene: 654591 Human
• 别名
  • AITD 3 antibody
  • AITD3 antibody
  • hTG antibody

  • TDH3 antibody
  • Tg antibody
  • TGN antibody
  • THYG_HUMAN antibody
  • Thyroglobulin antibody

  see all

实验方案

• Immunoprecipitation protocols
• Immunohistochemistry protocols
• Immunocytochemistry & immunofluorescence protocols
• Western blot protocols