概述

  • 产品名称Anti-Thyroglobulin抗体[EPR3614]
    参阅全部 Thyroglobulin 一抗
  • 描述
    兔单克隆抗体[EPR3614] to Thyroglobulin
  • 经测试应用适用于: WB, IP, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A synthetic peptide corresponding to residues within Human Thyroglobulin.

  • 阳性对照
    • WB: Human thyroid lysate IHC-P: Human papillary thyroid carcinoma
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

应用

Our Abpromise guarantee covers the use of ab92467 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/10000 - 1/20000. Predicted molecular weight: 305 kDa.
IP 1/50.
IHC-P 1/250 - 1/500.
ICC/IF Use at an assay dependent concentration. PubMed: 22517745

靶标

  • 功能Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
  • 组织特异性Thyroid gland specific.
  • 疾病相关Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
    Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
  • 序列相似性Belongs to the type-B carboxylesterase/lipase family.
    Contains 11 thyroglobulin type-1 domains.
  • 翻译后修饰Sulfated tyrosines are desulfated during iodination.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AITD 3 antibody
    • AITD3 antibody
    • hTG antibody
    • TDH3 antibody
    • Tg antibody
    • TGN antibody
    • THYG_HUMAN antibody
    • Thyroglobulin antibody
    see all

Anti-Thyroglobulin antibody [EPR3614] 图像

  • Anti-Thyroglobulin antibody [EPR3614] (ab92467) at 1/10000 dilution + Human thyroid lysate at 10 µg

    Secondary
    HRP labelled goat anti-rabbit IgG at 1/2000 dilution

    Predicted band size : 305 kDa
  • ab92467, at a 1/2500 dilution, staining Thyroglobulin in paraffin embedded Human papillary thyroid carcinoma tissue by Immunohistochemisty.

Anti-Thyroglobulin antibody [EPR3614] (ab92467)参考文献

This product has been referenced in:
  • Fernando R  et al. Human fibrocytes coexpress thyroglobulin and thyrotropin receptor. Proc Natl Acad Sci U S A 109:7427-32 (2012). ICC/IF ; Human . Read more (PubMed: 22517745) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab92467.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"