Anti-Thyroglobulin抗体(ab48628)

概述

  • 产品名称Anti-Thyroglobulin抗体
    参阅全部 Thyroglobulin 一抗
  • 描述
    兔多克隆抗体to Thyroglobulin
  • 经测试应用适用于: RIA, IP, WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length native protein (purified from plasma) (Human)

性能

应用

Our Abpromise guarantee covers the use of ab48628 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
RIA Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 307 kDa.
ELISA Use at an assay dependent concentration.

靶标

  • 功能Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
  • 组织特异性Thyroid gland specific.
  • 疾病相关Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
    Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
  • 序列相似性Belongs to the type-B carboxylesterase/lipase family.
    Contains 11 thyroglobulin type-1 domains.
  • 翻译后修饰Sulfated tyrosines are desulfated during iodination.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AITD 3 antibody
    • AITD3 antibody
    • hTG antibody
    • TDH3 antibody
    • Tg antibody
    • TGN antibody
    • THYG_HUMAN antibody
    • Thyroglobulin antibody
    see all

Anti-Thyroglobulin antibody 图像

  • Anti-Thyroglobulin antibody (ab48628) at 5 µg/ml + Natural Human Thyroglobulin protein (ab96518) at 0.01 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Exposure time : 10 seconds

Anti-Thyroglobulin antibody (ab48628)参考文献

ab48628 has not yet been referenced specifically in any publications.

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