概述
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产品名称Anti-Thymocytes抗体
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描述兔多克隆抗体to Thymocytes
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宿主Rabbit
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特异性ab112216 is strongly cytotoxic to Mouse thymocytes of all strains tested. ab112216 dilution which results in 50% cytotoxicity against thymus cells: 1/40000. Treatment of C57BL/6 splenocytes with ab112216 plus complement resulted in a reduction in the number of plaque-forming cells. As assessed by a CTL assay, T cell function was essentially eliminated in both pre-sensitized and post-sensitized treated samples. These results are consistent with the removal of T helper and T cytotoxicity cell activity.
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经测试应用适用于: Functional Studiesmore details
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种属反应性与反应: Mouse
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免疫原
Mouse Thymocytes
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阳性对照
- Mouse Thymus (Tested strains: C3H/He, AKR, A.TH, A.TL, BALB/c); C57BL/6 Splenocytes
性能
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形式Liquid
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存放说明Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
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存储溶液Constituent: 100% Whole serum
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Concentration information loading... -
纯度Preadsorbed antiserum
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纯化说明Heat Inactivation: 60 minutes at 56°C Adsorption: Mouse erythrocytes/hepatocytes
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab112216 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Functional Studies | 1/20 - 1/5000. Use at 1/1000 for depleting a cell population of Mouse thymocytes. |
靶标
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相关性Thymocytes are T cell precursors which develop in the thymus. The processes of beta-selection, positive selection and negative selection shape thymocytes into a peripheral pool of T cells that are able to respond to foreign pathogens and are immunologically tolerant towards self antigens.
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细胞定位Cell Membrane
图片
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Functional Studies - Thymocytes antibody (ab112216)Antiserum Titration determined by a two stage cytotoxicity assay:
Cell Source: Thymus
Donors: BALB/c
Cell Concentration: 1.1x106 cells per ml
文献
ab112216 has not yet been referenced specifically in any publications.
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"