Anti-Thymocytes抗体(ab112216)

概述

  • 产品名称Anti-Thymocytes抗体
  • 描述
    兔多克隆抗体to Thymocytes
  • 特异性ab112216 is strongly cytotoxic to Mouse thymocytes of all strains tested. ab112216 dilution which results in 50% cytotoxicity against thymus cells: 1/40000. Treatment of C57BL/6 splenocytes with ab112216 plus complement resulted in a reduction in the number of plaque-forming cells. As assessed by a CTL assay, T cell function was essentially eliminated in both pre-sensitized and post-sensitized treated samples. These results are consistent with the removal of T helper and T cytotoxicity cell activity.
  • 经测试应用适用于: Functional Studiesmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Mouse Thymocytes

  • 阳性对照
    • Mouse Thymus (Tested strains: C3H/He, AKR, A.TH, A.TL, BALB/c); C57BL/6 Splenocytes

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • 存储溶液Constituent: 100% Whole serum
  • Concentration information loading...
  • 纯度Preadsorbed antiserum
  • 纯化说明Heat Inactivation: 60 minutes at 56°C Adsorption: Mouse erythrocytes/hepatocytes
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab112216 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Functional Studies 1/20 - 1/5000.
Use at 1/1000 for depleting a cell population of Mouse thymocytes.

靶标

  • 相关性Thymocytes are T cell precursors which develop in the thymus. The processes of beta-selection, positive selection and negative selection shape thymocytes into a peripheral pool of T cells that are able to respond to foreign pathogens and are immunologically tolerant towards self antigens.
  • 细胞定位Cell Membrane

Anti-Thymocytes antibody 图像

  • Antiserum Titration determined by a two stage cytotoxicity assay:

    Cell Source: Thymus
    Donors: BALB/c
    Cell Concentration: 1.1x106 cells per ml

Anti-Thymocytes antibody (ab112216)参考文献

ab112216 has not yet been referenced specifically in any publications.

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