概述

  • 产品名称Anti-Thymidine Phosphorylase抗体
    参阅全部 Thymidine Phosphorylase 一抗
  • 描述
    兔多克隆抗体to Thymidine Phosphorylase
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Rat, Human
    预测可用于: Chimpanzee
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human Thymidine Phosphorylase.

    (Peptide available as ab69119.)

  • 阳性对照
    • This antibody gave a positive signal in the following Lysates: HeLa Whole Cell A431 Whole Cell HeLa Whole Cell - Bleomycin Treated (40 µM) A549 Whole Cell Rat Thymus Tissue (data not shown)

性能

应用

Our Abpromise guarantee covers the use of ab69120 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 50 kDa).

靶标

  • 功能May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
    Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
  • 通路Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2.
  • 疾病相关Mitochondrial DNA depletion syndrome 1 (MTDPS1) [MIM:603041]: A multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, cachexia, peripheral neuropathy, and myopathy. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • 序列相似性Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ECGF 1 antibody
    • ECGF antibody
    • ECGF1 antibody
    • Endothelial cell growth factor 1 antibody
    • Endothelial cell growth factor 1 platelet derived antibody
    • Endothelial cell growth factor, platelet-derived antibody
    • Gliostatin antibody
    • hPD ECGF antibody
    • MEDPS1 antibody
    • MNGIE antibody
    • MTDPS1 antibody
    • PD ECGF antibody
    • PD-ECGF antibody
    • PDECGF antibody
    • PDEGF antibody
    • Platelet derived endothelial cell growth factor antibody
    • Platelet derived endothelial growth factor antibody
    • Platelet-derived endothelial cell growth factor antibody
    • TdRPase antibody
    • Thymidine phosphorylase antibody
    • TP antibody
    • Tymp antibody
    • TYPH_HUMAN antibody
    see all

Anti-Thymidine Phosphorylase antibody 图像

  • All lanes : Anti-Thymidine Phosphorylase antibody (ab69120) at 1 µg/ml

    Lane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate
    Lane 2 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate
    Lane 3 : HeLa Whole Cell Lysate - Bleomycin Treated (40 µM)
    Lane 4 : A549 (Human lung adenocarcinoma epithelial cell line) Whole Cell Lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

    Performed under reducing conditions.

    Predicted band size : 50 kDa
    Observed band size : 50 kDa
    Additional bands at : 40 kDa. We are unsure as to the identity of these extra bands.

Anti-Thymidine Phosphorylase antibody (ab69120)参考文献

This product has been referenced in:
  • Torres-Torronteras J  et al. Gene Therapy Using a Liver-targeted AAV Vector Restores Nucleoside and Nucleotide Homeostasis in a Murine Model of MNGIE. Mol Ther N/A:N/A (2014). WB . Read more (PubMed: 24448160) »

See 1 Publication for this product

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