Anti-Thrombopoietin抗体(ab115679)

概述

  • 产品名称Anti-Thrombopoietin抗体
    参阅全部 Thrombopoietin 一抗
  • 描述
    兔多克隆抗体to Thrombopoietin
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide:

    KLLRDSHVLHSRLSQC

    conjugated to KLH, corresponding to amino acids 35-50 of Human Thrombopoietin (NP_000451.1).

  • 阳性对照
    • Human Spleen tissue.

性能

应用

Our Abpromise guarantee covers the use of ab115679 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1 - 1/1000.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
  • 疾病相关Defects in THPO are a cause of essential thrombocythemia (ET) [MIM:187950]. ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.
  • 序列相似性Belongs to the EPO/TPO family.
  • 结构域Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C mpl ligand antibody
    • C-mpl ligand antibody
    • Megakaryocyte colony stimulating factor antibody
    • Megakaryocyte colony-stimulating factor antibody
    • Megakaryocyte growth and development factor antibody
    • Megakaryocyte stimulating factor antibody
    • MGC163194 antibody
    • MGDF antibody
    • MKCSF antibody
    • ML antibody
    • MPL ligand antibody
    • MPLLG antibody
    • Myeloproliferative leukemia virus oncogene ligand antibody
    • Prepro thrombopoietin antibody
    • THCYT1 antibody
    • THPO antibody
    • Thrombopoietin antibody
    • Thrombopoietin nirs variant 1 antibody
    • TPO antibody
    • TPO_HUMAN antibody
    see all

Anti-Thrombopoietin antibody 图像

  • ab115679, at 10µg/ml, staining Thrombopoietin in Formalin-fixed, Paraffin-embedded Human Spleen tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Thrombopoietin antibody (ab115679)参考文献

ab115679 has not yet been referenced specifically in any publications.

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For ab112238: DISCOUNT CODE: ***
For ab115679: DISCOUNT CODE: ***
Expiration date: November 19, 2012

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