Anti-Thrombomodulin抗体[Phx-02] (ab24598)


  • 产品名称Anti-Thrombomodulin抗体[Phx-02]
    参阅全部 Thrombomodulin 一抗
  • 描述
    小鼠单克隆抗体[Phx-02] to Thrombomodulin
  • 经测试应用适用于: Flow Cyt, WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mammal
  • 免疫原

    Recombinant full length protein (Human)

  • 表位This antibody reacts with an epitope within the EGF 2 domain.



Our Abpromise guarantee covers the use of ab24598 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use at an assay dependent concentration. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
WB 1/500. Predicted molecular weight: 60 kDa.
ELISA 1/1000.


  • 功能Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
  • 组织特异性Endothelial cells are unique in synthesizing thrombomodulin.
  • 疾病相关Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THR-THBD) [MIM:188040]. A hemostatic disorder characterized by a tendency to thrombosis.
    Defects in THBD are a cause of susceptibility to hemolytic uremic syndrome atypical type 6 (AHUS6) [MIM:612926]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
  • 序列相似性Contains 1 C-type lectin domain.
    Contains 6 EGF-like domains.
  • 翻译后修饰N-glycosylated.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AHUS 6 antibody
    • AHUS6 antibody
    • BDCA 3 antibody
    • BDCA3 antibody
    • CD 141 antibody
    • CD141 antibody
    • CD141 antigen antibody
    • Fetomodulin antibody
    • Thbd antibody
    • THPH12 antibody
    • THRM antibody
    • Thrombomodulin antibody
    • TM antibody
    • TRBM_HUMAN antibody
    see all

Anti-Thrombomodulin antibody [Phx-02] (ab24598)参考文献

This product has been referenced in:
  • Liu SB  et al. A novel non-lens betagamma-crystallin and trefoil factor complex from amphibian skin and its functional implications. PLoS ONE 3:e1770 (2008). Read more (PubMed: 18335045) »

See 1 Publication for this product

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Typically ab24595 (Clone: PhX-01) has been used as a capture but both (ab24595 and ab24598) function as well as capture antibodies in ELISA, according to the literature references.

ab24595 reacts with an epitope within the EGF 5 domain an...

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If you have been testing antibodies in untested species or applications, you should have received testing discount codes. After submission of your Abreviews, those codes will be active an can be applied to a future ...

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Thank you for submitting an Abreview for ab24598. As you may have noticed, your review has now been published on our website.

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Abcam has not validated the combination of species/application used in this Abreview.
Application Western blot
Sample Pig Tissue lysate - whole (myocardium)
Loading amount 50 µg
Specification myocardium
Gel Running Conditions Reduced Denaturing (4-12% Bis-Tris)
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C

Rahul Dalal

Verified customer

提交于 Sep 17 2012