Anti-Thrombomodulin抗体[Phx-01] (ab24595)

概述

  • 产品名称Anti-Thrombomodulin抗体[Phx-01]
    参阅全部 Thrombomodulin 一抗
  • 描述
    小鼠单克隆抗体[Phx-01] to Thrombomodulin
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: all Mammals
  • 免疫原

    Recombinant full length protein (Human)

  • 表位This antibody reacts with an epitope within the EGF 5 domain.
  • 常规说明


    ab24595 inhibits thrombin binding.

性能

应用

Our Abpromise guarantee covers the use of ab24595 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Predicted molecular weight: 60 kDa.
ELISA 1/1000.

靶标

  • 功能Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
  • 组织特异性Endothelial cells are unique in synthesizing thrombomodulin.
  • 疾病相关Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THR-THBD) [MIM:188040]. A hemostatic disorder characterized by a tendency to thrombosis.
    Defects in THBD are a cause of susceptibility to hemolytic uremic syndrome atypical type 6 (AHUS6) [MIM:612926]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
  • 序列相似性Contains 1 C-type lectin domain.
    Contains 6 EGF-like domains.
  • 翻译后修饰N-glycosylated.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AHUS 6 antibody
    • AHUS6 antibody
    • BDCA 3 antibody
    • BDCA3 antibody
    • CD 141 antibody
    • CD141 antibody
    • CD141 antigen antibody
    • Fetomodulin antibody
    • Thbd antibody
    • THPH12 antibody
    • THRM antibody
    • Thrombomodulin antibody
    • TM antibody
    • TRBM_HUMAN antibody
    see all

Anti-Thrombomodulin antibody [Phx-01] (ab24595)参考文献

ab24595 has not yet been referenced specifically in any publications.

Product Wall

Typically ab24595 (Clone: PhX-01) has been used as a capture but both (ab24595 and ab24598) function as well as capture antibodies in ELISA, according to the literature references.


ab24595 reacts with an epitope within the EGF 5 domain an...

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