Anti-Thrombomodulin抗体[141C01], prediluted (ab74603)

概述

  • 产品名称Anti-Thrombomodulin抗体[141C01], prediluted
    参阅全部 Thrombomodulin 一抗
  • 描述
    小鼠单克隆抗体[141C01] to Thrombomodulin, prediluted
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Rat, Human
  • 免疫原

    Recombinant protein encoding the six repeated EGF domains of human Thrombomodulin

  • 表位EGF domain
  • 阳性对照
    • Mesothelioma and human placenta tissue.

性能

应用

Our Abpromise guarantee covers the use of ab74603 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: Ready to use.
    Staining of formalin-fixed tissues requires boiling tisssue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
    • 组织特异性Endothelial cells are unique in synthesizing thrombomodulin.
    • 疾病相关Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THR-THBD) [MIM:188040]. A hemostatic disorder characterized by a tendency to thrombosis.
      Defects in THBD are a cause of susceptibility to hemolytic uremic syndrome atypical type 6 (AHUS6) [MIM:612926]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
    • 序列相似性Contains 1 C-type lectin domain.
      Contains 6 EGF-like domains.
    • 翻译后修饰N-glycosylated.
      The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AHUS 6 antibody
      • AHUS6 antibody
      • BDCA 3 antibody
      • BDCA3 antibody
      • CD 141 antibody
      • CD141 antibody
      • CD141 antigen antibody
      • Fetomodulin antibody
      • Thbd antibody
      • THPH12 antibody
      • THRM antibody
      • Thrombomodulin antibody
      • TM antibody
      • TRBM_HUMAN antibody
      see all

    Anti-Thrombomodulin antibody [141C01], prediluted (ab74603)参考文献

    ab74603 has not yet been referenced specifically in any publications.

    Product Wall

    Here are the two discount codes for the Thrombomodulin antibodies we were looking at today, followed by an explanation of how to activate and use them.

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    These codes will give you one free primary antibody per code before the expi...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"