Anti-Thrombin Receptor抗体(ab111976)

概述

  • 产品名称
    Anti-Thrombin Receptor抗体
    参阅全部 Thrombin Receptor 一抗
  • 描述
    山羊多克隆抗体to Thrombin Receptor
  • 经测试应用
    适用于: WB, IHC-P, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    TRARRPESKATNAT

    by a Cysteine residue linker, corresponding to internal sequence amino acids 24-37 of Human Thrombin Receptor (NP_001983.2).

  • 阳性对照
    • HeLa lysate; Human liver tissue.

性能

应用

Our Abpromise guarantee covers the use of ab111976 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 47 kDa.
IHC-P Use a concentration of 2.5 µg/ml.
ELISA 1/3200.

靶标

  • 功能
    High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
  • 组织特异性
    Platelets and vascular endothelial cells.
  • 序列相似性
    Belongs to the G-protein coupled receptor 1 family.
  • 翻译后修饰
    A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
    Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.
  • 细胞定位
    Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CF2R antibody
    • Coagulation factor II (thrombin) receptor antibody
    • Coagulation factor II receptor antibody
    • F2R antibody
    • HTR antibody
    • PAR 1 antibody
    • PAR-1 antibody
    • PAR1 antibody
    • PAR1_HUMAN antibody
    • Protease activated receptor 1 antibody
    • Proteinase activated receptor 1 antibody
    • Proteinase-activated receptor 1 antibody
    • Thrombin receptor antibody
    • TR antibody
    see all

图片

  • ab111976, at 2.5µg/ml, staining Thrombin Receptor in Formalin-fixed, Paraffin-embedded Human Liver tissue by Immunohistochemistry.
  • Anti-Thrombin Receptor antibody (ab111976) at 0.5 µg/ml + HeLa lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 47 kDa

文献

ab111976 has not yet been referenced specifically in any publications.

客户评价及客户问答

Thank you for contacting us.

The Uniprot http://www.uniprot.org/uniprot/P25116 database shows, the active part of protein "human Proteinase-activated receptor 1" has amino acid sequence between 42-425, so antibodies specific to this ...

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thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products.

I am sorry this product did not perform as stated on the datasheet and for the inconvenience this h...

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Are the platelets from Human? This provides us with vital information for monitoring product quality.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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