Anti-PAR1/Thrombin Receptor抗体(ab111976)
Key features and details
- Goat polyclonal to PAR1/Thrombin Receptor
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-PAR1/Thrombin Receptor抗体
参阅全部 PAR1/Thrombin Receptor 一抗 -
描述
山羊多克隆抗体to PAR1/Thrombin Receptor -
宿主
Goat -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human PAR1/Thrombin Receptor aa 1-100 (internal sequence) (Cysteine residue).
Database link: NP_001983.2 -
阳性对照
- HeLa lysate; Human liver tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA -
Concentration information loading...
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纯度
Protein G purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab111976于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 47 kDa.
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IHC-P |
Use a concentration of 2.5 µg/ml.
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说明 |
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WB
Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 47 kDa. |
IHC-P
Use a concentration of 2.5 µg/ml. |
靶标
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功能
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. -
组织特异性
Platelets and vascular endothelial cells. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
翻译后修饰
A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 2149 Human
- Omim: 187930 Human
- SwissProt: P25116 Human
- Unigene: 482562 Human
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别名
- CF2R antibody
- Coagulation factor II (thrombin) receptor antibody
- Coagulation factor II receptor antibody
see all
图片
数据表及文件
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Datasheet download
文献 (2)
ab111976 被引用在 2 文献中.
- Sébert M et al. Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease-activated receptor 1- and protease-activated receptor 4-dependent mechanism. Br J Pharmacol 175:3656-3668 (2018). PubMed: 29959891
- Desormeaux C et al. Protease-activated receptor 1 is implicated in irritable bowel syndrome mediators-induced signaling to thoracic human sensory neurons. Pain 159:1257-1267 (2018). PubMed: 29554016