Anti-THOC5抗体[EPR6905(B)] (ab124996)


  • 产品名称Anti-THOC5抗体[EPR6905(B)]
    参阅全部 THOC5 一抗
  • 描述
    兔单克隆抗体[EPR6905(B)] to THOC5
  • 经测试应用适用于: WBmore details
    不适用于: Flow Cyt,ICC,IHC-P or IP
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues in Human THOC5.

  • 阳性对照
    • 293T, HeLa, NIH 3T3 and A549 cell lysates.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.


  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 解离常数(KD KD = 4.40 x 10 -11 M Learn more about KD
  • 存储溶液pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
  • 纯度Tissue culture supernatant
  • 克隆单克隆
  • 克隆编号EPR6905(B)
  • 同种型IgG
  • 研究领域


Our Abpromise guarantee covers the use of ab124996 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 79 kDa (predicted molecular weight: 79 kDa).
  • 应用说明Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • 靶标

    • 功能Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and ALYREF/THOC4. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA. Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.
    • 组织特异性Ubiquitously expressed.
    • 序列相似性Belongs to the THOC5 family.
    • 翻译后修饰Phosphorylated on tyrosine upon binding to activated CSF1R; which causes a dissociation of the two proteins. Phosphorylation on Ser-5 and/or Ser-6 is required for nuclear export. Phosphorylated on Thr-328 in insulin-stimulated adipocytes (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Nucleus. Cytoplasm. Shuttles between nucleus and cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C22orf19 antibody
      • Chromosome 22 open reading frame 19 antibody
      • Fmip antibody
      • Fms interacting protein antibody
      • fSAP79 antibody
      • Functional spliceosome-associated protein 79 antibody
      • hTREX90 antibody
      • KIAA0983 antibody
      • LOC400922 antibody
      • NF2/meningioma region protein pK1.3 antibody
      • PK1.3 antibody
      • Placental protein 39.2 antibody
      • PP39.2 antibody
      • THO complex 5 antibody
      • THO complex subunit 5 antibody
      • THO complex subunit 5 homolog antibody
      • thoc5 antibody
      • THOC5_HUMAN antibody
      see all

    Anti-THOC5 antibody [EPR6905(B)] 图像

    • All lanes : Anti-THOC5 antibody [EPR6905(B)] (ab124996) at 1/1000 dilution

      Lane 1 : 293T cell lysate
      Lane 2 : HeLa cell lysate
      Lane 3 : NIH 3T3 cell lysate
      Lane 4 : A549 cell lysate

      Lysates/proteins at 10 µg per lane.

      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 79 kDa
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    Anti-THOC5 antibody [EPR6905(B)] (ab124996)参考文献

    ab124996 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab124996.
    Please use the links above to contact us or submit feedback about this product.