Anti-Thioredoxin / TRX抗体[8A1] (ab16845)


  • 产品名称Anti-Thioredoxin / TRX抗体[8A1]
    参阅全部 Thioredoxin / TRX 一抗
  • 描述
    小鼠单克隆抗体[8A1] to Thioredoxin / TRX
  • 经测试应用适用于: ELISA, IP, WBmore details
  • 种属反应性
    与反应: Human
    不与反应: Mouse, Rat
  • 免疫原

    Recombinant full length protein (Human).

  • 阳性对照
    • 293T whole cell lysate.



Our Abpromise guarantee covers the use of ab16845 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
IP Use a concentration of 1 - 2 µg/ml.
WB Use at an assay dependent dilution.


  • 功能Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
    ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
  • 序列相似性Belongs to the thioredoxin family.
    Contains 1 thioredoxin domain.
  • 翻译后修饰In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins.
    In case of infection, ubiquitinated by S.typhimurium protein slrP, leading to its degradation.
  • 细胞定位Nucleus. Cytoplasm. Secreted. Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ADF antibody
    • ATL derived factor antibody
    • ATL-derived factor antibody
    • DKFZp686B1993 antibody
    • MGC61975 antibody
    • SASP antibody
    • Surface associated sulphydryl protein antibody
    • Surface-associated sulphydryl protein antibody
    • THIO_HUMAN antibody
    • Thioredoxin antibody
    • TRDX antibody
    • TRX 1 antibody
    • Trx antibody
    • TRX1 antibody
    • TXN antibody
    • TXN protein antibody
    • zgc:92903 antibody
    see all

Anti-Thioredoxin / TRX antibody [8A1] 图像

  • Immunoprecipitation analysis of 293T cell lysates using ab16845.

    Lane 1: Input.

    Lane 2: Precipitates.

Anti-Thioredoxin / TRX antibody [8A1] (ab16845)参考文献

This product has been referenced in:
  • Yu Y & Richardson DR Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1. J Biol Chem 286:15413-27 (2011). IP . Read more (PubMed: 21378396) »
  • Tipple TE  et al. Alterations of the thioredoxin system by hyperoxia: implications for alveolar development. Am J Respir Cell Mol Biol 41:612-9 (2009). Read more (PubMed: 19244202) »

See all 2 Publications for this product

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Thank you for your enquiry. The Abs that you have expressed an interest in have not been tested in conjunction with each other to use in a sandwich ELISA. These products are suitable for use either in direct or indirect ELISA. If you wish to set up a s...

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