The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.3 - 3 µg/ml. Predicted molecular weight: 73 kDa.
功能Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.
序列相似性Belongs to the themis family.
翻译后修饰Phosphorylated on Tyr residues quickly after TCR stimulation.