Anti-THAP1抗体(ab57481)

概述

  • 产品名称Anti-THAP1抗体
    参阅全部 THAP1 一抗
  • 描述
    小鼠单克隆抗体to THAP1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-214 of Human THAP1

性能

应用

Our Abpromise guarantee covers the use of ab57481 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
    • 疾病相关Defects in THAP1 are the cause of dystonia type 6 (DYT6) [MIM:602629]. DYT6 is a primary torsion dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Dystonia type 6 is characterized by onset in early adulthood, cranial or cervical involvement in about half of the cases, and frequent progression to involve multiple body regions.
    • 序列相似性Belongs to the THAP1 family.
      Contains 1 THAP-type zinc finger.
    • 细胞定位Nucleus > nucleoplasm. Nucleus > PML body.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 4833431A01Rik antibody
      • FLJ10477 antibody
      • MGC33014 antibody
      • Nuclear proapoptotic factor antibody
      • THAP 1 antibody
      • THAP domain containing apoptosis associated protein 1 antibody
      • THAP domain containing protein 1 antibody
      • THAP domain protein 1 antibody
      • THAP domain-containing protein 1 antibody
      • Thap1 antibody
      • THAP1_HUMAN antibody
      see all

    Anti-THAP1 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57481 THAP1 antibody at 1ug/ml. Predicted band size of immunogen is 50 kDa

    Anti-THAP1 antibody (ab57481)参考文献

    ab57481 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your enquiry. The immunogen sequence for this product is as below. Immunogen: THAP1 (1 a.a. ~ 214 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence (without GST tag): ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"