概述

  • 产品名称Anti-THAP1抗体
    参阅全部 THAP1 一抗
  • 描述
    兔多克隆抗体to THAP1
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human THAP1 protein (NP_060575.1)

  • 阳性对照
    • Jurkat cell lysate, transfected 293T cell lysate

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab118368 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 25 kDa.
IP Use at an assay dependent dilution.

靶标

  • 功能DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
  • 疾病相关Defects in THAP1 are the cause of dystonia type 6 (DYT6) [MIM:602629]. DYT6 is a primary torsion dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Dystonia type 6 is characterized by onset in early adulthood, cranial or cervical involvement in about half of the cases, and frequent progression to involve multiple body regions.
  • 序列相似性Belongs to the THAP1 family.
    Contains 1 THAP-type zinc finger.
  • 细胞定位Nucleus > nucleoplasm. Nucleus > PML body.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 4833431A01Rik antibody
    • FLJ10477 antibody
    • MGC33014 antibody
    • Nuclear proapoptotic factor antibody
    • THAP 1 antibody
    • THAP domain containing apoptosis associated protein 1 antibody
    • THAP domain containing protein 1 antibody
    • THAP domain protein 1 antibody
    • THAP domain-containing protein 1 antibody
    • Thap1 antibody
    • THAP1_HUMAN antibody
    see all

Anti-THAP1 antibody 图像

  • Anti-THAP1 antibody (ab118368) at 1/1000 dilution + Jurkat cell lystate at 50 µg

    Predicted band size : 25 kDa
  • All lanes : Anti-THAP1 antibody (ab118368) at 1/1000 dilution

    Lane 1 : THAP1 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 25 kDa
  • Immunoprecipitation of THAP1 transfected lysate using ab118368 and Protein A Magnetic Bead. Detected using another antibody to THAP1.

Anti-THAP1 antibody (ab118368)参考文献

ab118368 has not yet been referenced specifically in any publications.

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