Anti-TGF beta Receptor I抗体, prediluted (ab53647)

概述

  • 产品名称Anti-TGF beta Receptor I抗体, prediluted
    参阅全部 TGF beta Receptor I 一抗
  • 描述
    兔多克隆抗体to TGF beta Receptor I, prediluted
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Sheep, Horse, Chicken, Cow, Pig, Xenopus laevis
  • 免疫原

    Synthetic peptide:

    VPNEEDPSLDRPFISEGTTLKD

    , corresponding to amino acids 158-179 of Human TGF beta Receptor I

  • 阳性对照
    • Human placenta tissue A549 cell

性能

应用

Our Abpromise guarantee covers the use of ab53647 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: Ready-to-use for 30 min at RT. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.
    • 组织特异性Found in all tissues examined, most abundant in placenta and least abundant in brain and heart.
    • 疾病相关Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 1A (LDS1A) [MIM:609192]; also known as Furlong syndrome or Loeys-Dietz aortic aneurysm syndrome (LDAS). LDS1 is an aortic aneurysm syndrome with widespread systemic involvement. The disorder is characterized by arterial tortuosity and aneurysms, craniosynostosis, hypertelorism, and bifid uvula or cleft palate. Other findings include exotropy, micrognathia and retrognathia, structural brain abnormalities, intellectual deficit, congenital heart disease, translucent skin, joint hyperlaxity and aneurysm with dissection throughout the arterial tree.
      Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 2A (LDS2A) [MIM:608967]. LDS2 is an aortic aneurysm syndrome with widespread systemic involvement. Physical findings include prominent joint laxity, easy bruising, wide and atrophic scars, velvety and translucent skin with easily visible veins, spontaneous rupture of the spleen or bowel, diffuse arterial aneurysms and dissections, and catastrophic complications of pregnancy, including rupture of the gravid uterus and the arteries, either during pregnancy or in the immediate postpartum period. LDS2 is characterized by the absence of craniofacial abnormalities with the exception of bifid uvula that can be present in some patients.
      Defects in TGFBR1 are the cause of aortic aneurysm familial thoracic type 5 (AAT5) [MIM:608967]. Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as 'medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
    • 序列相似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
      Contains 1 GS domain.
      Contains 1 protein kinase domain.
    • 翻译后修饰Phosphorylated at basal levels in the absence of ligand binding. Activated by multiple phosphorylation, mainly in the GS region.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AAT 5 antibody
      • AAT5 antibody
      • Activin A receptor type II like kinase 53kDa antibody
      • Activin A receptor type II like kinase, 53kD antibody
      • Activin A receptor type II like protein kinase of 53kD antibody
      • activin A receptor type II-like kinase, 53kDa antibody
      • activin A receptor type II-like protein kinase of 53kD antibody
      • Activin receptor like kinase 5 antibody
      • Activin receptor-like kinase 5 antibody
      • ACVRLK 4 antibody
      • ACVRLK4 antibody
      • ALK 5 antibody
      • ALK-5 antibody
      • ALK5 antibody
      • LDS1A antibody
      • LDS2A antibody
      • MSSE antibody
      • Serine/threonine protein kinase receptor R4 antibody
      • Serine/threonine-protein kinase receptor R4 antibody
      • SKR 4 antibody
      • SKR4 antibody
      • TbetaR I antibody
      • TbetaR-I antibody
      • TGF beta receptor type 1 antibody
      • TGF beta receptor type I antibody
      • TGF beta type I receptor antibody
      • TGF-beta receptor type I antibody
      • TGF-beta receptor type-1 antibody
      • TGF-beta type I receptor antibody
      • TGFBR 1 antibody
      • TGFBR1 antibody
      • TGFBR1 protein antibody
      • TGFR 1 antibody
      • TGFR-1 antibody
      • TGFR1 antibody
      • TGFR1_HUMAN antibody
      • Transforming growth factor beta receptor 1 antibody
      • Transforming growth factor beta receptor I (activin A receptor type II like kinase, 53kD) antibody
      • Transforming growth factor beta receptor I antibody
      • transforming growth factor, beta receptor 1 antibody
      • transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD) antibody
      • Transforming growth factor-beta receptor type I antibody
      see all

    Anti-TGF beta Receptor I antibody, prediluted 图像

    • ab53647, used neat, staining Human TGF beta receptor 1 in Placenta, using Immunohistochemistry, Formalin Fixed Paraffin Embedded tissue.

    Anti-TGF beta Receptor I antibody, prediluted (ab53647)参考文献

    ab53647 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab53647.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"