功能Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
组织特异性Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.
序列相似性Belongs to the TALE/TGIF homeobox family. Contains 1 homeobox DNA-binding domain.
翻译后修饰The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway.