Anti-TGF beta 3抗体(ab53727)

概述

  • 产品名称
    Anti-TGF beta 3抗体
    参阅全部 TGF beta 3 一抗
  • 描述
    兔多克隆抗体to TGF beta 3
  • 特异性
    Detects endogenous levels of total TGF ß3 protein.
  • 经测试应用
    适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from human TGF ß3.

  • 阳性对照
    • Extracts from COS7 cells.

性能

应用

Our Abpromise guarantee covers the use of ab53727 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 47 kDa.
ELISA 1/10000.

靶标

  • 功能
    Involved in embryogenesis and cell differentiation.
  • 疾病相关
    Defects in TGFB3 are a cause of familial arrhythmogenic right ventricular dysplasia type 1 (ARVD1) [MIM:107970]; also known as arrhythmogenic right ventricular cardiomyopathy 1 (ARVC1). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
  • 序列相似性
    Belongs to the TGF-beta family.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ARVD antibody
    • ARVD1 antibody
    • FLJ16571 antibody
    • LDS5 antibody
    • MGC105479 antibody
    • MGC118722 antibody
    • prepro-transforming growth factor beta-3 antibody
    • RNHF antibody
    • TGF beta 3 antibody
    • TGF beta3 antibody
    • TGF-beta-3 antibody
    • TGFB 3 antibody
    • Tgfb3 antibody
    • TGFB3_HUMAN antibody
    • transforming growth factor beta 3 antibody
    • Transforming growth factor beta-3 antibody
    see all

Anti-TGF beta 3 antibody 图像

  • All lanes : Anti-TGF beta 3 antibody (ab53727) at 1/500 dilution

    Lane 1 : extracts from COS7 cells
    Lane 2 : extracts from COS7 cells with immunizing peptide


    Performed under reducing conditions.

    Predicted band size : 47 kDa
    Observed band size : 11 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 65 kDa (possible non-specific binding).

    The active molecule is a nonglycosylated, homodimer comprised of 13-kDa polypeptide chains linked by disulphide bonds.

实验方案

Anti-TGF beta 3 antibody (ab53727)参考文献

ab53727 has not yet been referenced specifically in any publications.

Product Wall

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ab9758 - the major band at44.3 kDa corresponding to the unprocessed (pre-pro-TGF beta 1) form, the mature processed TGF beta 1 is a 25 kD homodimer composed of two 12.5 kDa subunits joined by disulfide bonds. As th...

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The immunogen is 10aa long. The cross-reactivity against TGFb1 and TGFb2 has not been determined. However, the homology with the immunogen is 80% for both sequences. Thus, cross-reactivity could be possible.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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