概述

  • 产品名称
  • 描述
    兔多克隆抗体to TFPT
  • 经测试应用
    适用于: ICC/IF, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence: RLHQVQRITR RLQQERRFLM RVLDSYGDDY RASQFTIVLE DEGSQGTDAP TPGNAENEPP EKETLS, corresponding to amino acids 102-167 of Human TFPT (UniProt ID: P0C1Z6).

  • 阳性对照
    • Human liver tissue

性能

应用

Our Abpromise guarantee covers the use of ab122236 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    Appears to promote apoptosis in a p53/TP53-independent manner.
    Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
  • 疾病相关
    Note=A chromosomal aberration involving TFPT is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Inversion inv(19)(p13;q13) with TCF3.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Amida antibody
    • INO80 complex subunit F antibody
    • INO80F antibody
    • Protein FB1 antibody
    • TCF3 (E2A) fusion partner (in childhood Leukemia) antibody
    • TCF3 fusion partner antibody
    • TFPT antibody
    • TFPT_HUMAN antibody
    see all

图片

  • Immunofluorescent staining of Human cell line A-431 shows positivity in nucleus and nucleoli. Recommended concentration of ab122236 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab122236, at a dilution of 1/250, staining TFPT in paraffin embedded Human liver tissue by Immunohistochemistry.

文献

ab122236 has not yet been referenced specifically in any publications.

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