概述

  • 产品名称Anti-TFB2M抗体
    参阅全部 TFB2M 一抗
  • 描述
    山羊多克隆抗体to TFB2M
  • 经测试应用适用于: ICC/IF, WBmore details
  • 种属反应性
    与反应: Rat, Human
  • 免疫原

    Synthetic peptide:

    CAYKWLYDETLEDR

    , corresponding to C terminal amino acids 383-396 of Human TFB2M.

  • 常规说明GenBank Accession Number - NP_071761

性能

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应用

Our Abpromise guarantee covers the use of ab13676 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent dilution. PubMed: 21113058
WB Use at an assay dependent dilution. Can be blocked with Human TFB2M peptide (ab23228). Preliminary experiments gave an approx 40kDa band in Human Brain lysate at 0.3 ug/ml. Please note that currently we cannot find an explanation in the literature for the band we observe given the predicted size of approx. 46kDda according to NP_071761

靶标

  • 功能S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.
  • 组织特异性Ubiquitously expressed.
  • 序列相似性Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
  • 细胞定位Mitochondrion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • N''-adenosyl(rRNA) dimethyltransferase 2 antibody
    • S adenosylmethionine 6 N', N' adenosyl(rRNA) dimethyltransferase 2 antibody
    • Dimethyladenosine transferase 2 antibody
    • dimethyladenosine transferase 2 mitochondrial antibody
    • FLJ22661 antibody
    • FLJ23182 antibody
    • h mtTFB antibody
    • h mtTFB2 antibody
    • h-mtTFB antibody
    • h-mtTFB2 antibody
    • HCV NS5A transactivated protein 5 antibody
    • HCV NS5A-transactivated protein 5 antibody
    • hepatitis C virus NS5A transactivated protein 5 antibody
    • Hepatitis C virus NS5A-transactivated protein 5 antibody
    • Hkp1 antibody
    • hTFB2M antibody
    • Mitochondrial 12S rRNA dimethylase 2 antibody
    • mitochondrial antibody
    • Mitochondrial dimethyladenosine transferase 2 antibody
    • Mitochondrial transcription factor B2 antibody
    • mtTFB antibody
    • mtTFB2 antibody
    • NS5ATP5 antibody
    • S-adenosylmethionine-6-N'' antibody
    • TFB2M antibody
    • TFB2M_HUMAN antibody
    • Transcription Factor B2 antibody
    • Transcription factor B2 mitochondrial antibody
    see all

Anti-TFB2M antibody (ab13676)参考文献

This product has been referenced in:
  • Watanabe A  et al. Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription. Cardiovasc Res 90:57-67 (2011). ICC/IF ; Rat . Read more (PubMed: 21113058) »
  • Minczuk M  et al. TEFM (c17orf42) is necessary for transcription of human mtDNA. Nucleic Acids Res 39:4284-4299 (2011). WB ; Human . Read more (PubMed: 21278163) »

See all 2 Publications for this product

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