概述

  • 产品名称
  • 描述
    兔多克隆抗体to TEP1
  • 经测试应用
    适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Human TEP1 (N terminal). 20 amino acid from near the N-terminus of Human TEP1.

  • 阳性对照
    • Human skin tissue. Human breast tissue.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab64189 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 290 kDa.
IHC-P Use a concentration of 5 µg/ml.

靶标

  • 相关性
    Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TEP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TEP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.
  • 细胞定位
    Nuclear (probable). Telomere.
  • 数据库链接
  • 别名
    • p240 antibody
    • p80 telomerase homolog antibody
    • Telomerase associated protein 1 antibody
    • Telomerase protein component 1 antibody
    • TLP1 antibody
    • TP1 antibody
    • TROVE domain family, member 1 antibody
    • TROVE1 antibody
    • VAULT2 antibody
    see all

图片

  • ab64189 (5ug/ml) staining TEP1 in human skin tissue by immunohistochemistry using formalin-fixed, paraffin-embedded tissue.
  • ab64189 (5ug/ml) staining TEP1 in human breast tissue by immunohistochemistry using formalin-fixed, paraffin embedded tissue.

文献

ab64189 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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