概述

  • 产品名称Anti-Tenascin C抗体[DB7]
    参阅全部 Tenascin C 一抗
  • 描述
    小鼠单克隆抗体[DB7] to Tenascin C
  • 特异性ab86182 reacts with the fibrinogen like knob domain of Tenascin C.
  • 经测试应用适用于: IP, WB, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Tenascin polypeptides from spent culture supernatant of human fibroblasts isolated by affinity chromatography.

  • 常规说明


    ab86182 is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.

性能

应用

Our Abpromise guarantee covers the use of ab86182 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at an assay dependent concentration.
WB 1/1000. Predicted molecular weight: 241 kDa.
IHC-P Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration.

靶标

  • 功能Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
  • 序列相似性Belongs to the tenascin family.
    Contains 15 EGF-like domains.
    Contains 1 fibrinogen C-terminal domain.
    Contains 15 fibronectin type-III domains.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 150 225 antibody
    • Cytotactin antibody
    • Glioma associated extracellular matrix antigen antibody
    • Glioma-associated-extracellular matrix antigen antibody
    • GMEM antibody
    • GP 150 225 antibody
    • GP 150-225 antibody
    • GP antibody
    • Hexabrachion antibody
    • HXB antibody
    • JI antibody
    • MGC167029 antibody
    • Miotendinous antigen antibody
    • Myotendinous antigen antibody
    • Neuronectin antibody
    • TENA_HUMAN antibody
    • Tenascin antibody
    • Tenascin-C antibody
    • Tenascin-C isoform 14/AD1/16 antibody
    • TenascinC antibody
    • TN antibody
    • TN C antibody
    • TN-C antibody
    • TNC antibody
    see all

Anti-Tenascin C antibody [DB7] 图像

  • Immunohistochemical analysis of Human cornea tissue, staining Tenascin C wih ab86182.

    Tissue was taken from healthy patients (left) or patients with granular dystrophy (right). Sections were blocked with blocking solution for 30 minutes at room temperature before incubation with primary antibody (1/50) overnight at 4°C. Staining was detected with DAB.

Anti-Tenascin C antibody [DB7] (ab86182)参考文献

This product has been referenced in:
  • Szalai E  et al. Fibrillin-2, tenascin-C, matrilin-2, and matrilin-4 are strongly expressed in the epithelium of human granular and lattice type I corneal dystrophies. Mol Vis 18:1927-36 (2012). IHC-P ; Human . Read more (PubMed: 22876117) »
  • Tiitta O  et al. Enhanced tenascin expression in cervical and vulvar koilocytotic lesions. Am J Pathol 141:907-13 (1992). Read more (PubMed: 1384340) »

See all 2 Publications for this product

Product Wall

Muchas gracias por tu respuesta.

Es importante que todos los anticuerpos que escojas para llevar a cabo IHC-P en tejido humano estén validados (y por tanto garantizados por Abcam) para funcionar en esta especie y aplicación. Est...

Read More

Thank you once again for your recent enquiries and I appreciate your patience in waiting for a reply.

I have now received information from the originator, who have confirm that regrettably, we do not have a blocking peptide to provide for th...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"