概述

  • 产品名称Anti-TEM8抗体
    参阅全部 TEM8 一抗
  • 描述
    兔多克隆抗体to TEM8
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    This polyclonal antibody was raised by immunizing rabbit with human TEM8 synthetic peptide, located near its N-terminal domain.

性能

应用

Our Abpromise guarantee covers the use of ab34268 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明ELISA: 1/5000.
    WB: 1/5000 for analysis of recombinant protein, 1/400 for analysis of tissue extracts or cell lysates. Predicted molecular weight: 63 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
    • 组织特异性Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
    • 疾病相关Defects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:602089]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma.
    • 序列相似性Belongs to the ATR family.
      Contains 1 VWFA domain.
    • 结构域Binding to PA occurs through the VWA domain.
    • 细胞定位Cell membrane. Cell projection > lamellipodium membrane. Cell projection > filopodium membrane. At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Anthrax toxin receptor 1 antibody
      • ANTR1_HUMAN antibody
      • Antxr1 antibody
      • ATR antibody
      • Tumor endothelial marker 8 antibody
      see all

    Anti-TEM8 antibody (ab34268)参考文献

    ab34268 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"