Anti-TEM8抗体(ab21269)

概述

  • 产品名称Anti-TEM8抗体
    参阅全部 TEM8 一抗
  • 描述
    兔多克隆抗体to TEM8
  • 特异性This antibody will recognize only the largest isoform of TEM8.
  • 经测试应用适用于: ICC/IF, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to 13 amino acids near the C-terminal of TEM8 (Human).

  • 阳性对照
    • K562 cell lysates.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab21269 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 2 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 63 kDa.

靶标

  • 功能Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
  • 组织特异性Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
  • 疾病相关Defects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:602089]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma.
  • 序列相似性Belongs to the ATR family.
    Contains 1 VWFA domain.
  • 结构域Binding to PA occurs through the VWA domain.
  • 细胞定位Cell membrane. Cell projection > lamellipodium membrane. Cell projection > filopodium membrane. At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Anthrax toxin receptor 1 antibody
    • ANTR1_HUMAN antibody
    • Antxr1 antibody
    • ATR antibody
    • Tumor endothelial marker 8 antibody
    see all

Anti-TEM8 antibody 图像

  • Lane 1 : Anti-TEM8 antibody (ab21269) at 0.5 µg/ml
    Lane 2 : Anti-TEM8 antibody (ab21269) at 1 µg/ml
    Lane 3 : Anti-TEM8 antibody (ab21269) at 2 µg/ml

    Lane 1 : K562 cell lysate
    Lane 2 : K562 cell lysate
    Lane 3 : K562 cell lysate


    Predicted band size : 63 kDa
  • ab21269 at 2µg/ml staining TEM8 in K562 cells by ICC/IF

Anti-TEM8 antibody (ab21269)参考文献

ab21269 has not yet been referenced specifically in any publications.

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To our knowledge, neither of these antibodies have been used in any references yet. All of the known references for our products can be found on the Specific References tab of the online datasheet. Please let me k...

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The attached ICC/IF protocol was used to validate ab129004 but would also be suitable for use with ab21269. The recommended dilutions for these antibodies are 1:250 - 500. I hope this helps, please let me know if ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"