Anti-TEM8抗体[200C1339] (ab13798)

概述

• 产品名称Anti-TEM8抗体[200C1339]
  参阅全部 TEM8 一抗
• 描述
  小鼠单克隆抗体[200C1339] to TEM8
• 经测试应用适用于: WB, IHC-Pmore details
• 种属反应性
  与反应: Human
  
• 免疫原

  Synthetic peptide:

  CINFTRVKNNQPAKYPL

  , corresponding to amino acids 481-497 of Human TEM8.
  Run BLAST with Run BLAST with
• 阳性对照
  • Tested with TEM8 transfected cell lysate.

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存储溶液Preservative: 0.05% Sodium azide
  Constituents: PBS, 0.05% BSA
• Concentration information loading...
• 纯度Protein G purified
• 克隆单克隆
• 克隆编号200C1339
• 同种型IgG
• 研究领域
  • Tags & Cell Markers
  • Cell Type Markers
  • Tumor Associated

  • Microbiology
  • Protein
  • Human Protein
  • Defensin

  • Tags & Cell Markers
  • Cell Type Markers
  • Epi / Endo-thelial

  • Cardiovascular
  • Angiogenesis
  • Angiogenic Factors

  • Cardiovascular
  • Angiogenesis
  • Endothelial Cell Markers

相关产品

• Compatible Secondaries
  • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
  • Goat Anti-Mouse IgG H&L (HRP) (ab205719)

应用

靶标

• 功能Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
• 组织特异性Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
• 疾病相关Defects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:602089]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma.
• 序列相似性Belongs to the ATR family.
  Contains 1 VWFA domain.
• 结构域Binding to PA occurs through the VWA domain.
• 细胞定位Cell membrane. Cell projection > lamellipodium membrane. Cell projection > filopodium membrane. At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.

• Target information above from: UniProt accession Q9H6X2 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 84168 Human
  • Omim: 606410 Human
  • SwissProt: Q9H6X2 Human
  • Unigene: 165859 Human
• 别名
  • Anthrax toxin receptor 1 antibody
  • ANTR1_HUMAN antibody
  • Antxr1 antibody

  • ATR antibody
  • Tumor endothelial marker 8 antibody

  see all