概述

  • 产品名称Anti-TEM8抗体[200C1339]
    参阅全部 TEM8 一抗
  • 描述
    小鼠单克隆抗体[200C1339] to TEM8
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    CINFTRVKNNQPAKYPL

    , corresponding to amino acids 481-497 of Human TEM8.

  • 阳性对照
    • Tested with TEM8 transfected cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab13798 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 84 kDa.

A 70 kD band was seen when cell extracts were treated with a glycosidase cocktail. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

IHC-P 1/200 - 1/400. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
  • 组织特异性Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
  • 疾病相关Defects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:602089]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma.
  • 序列相似性Belongs to the ATR family.
    Contains 1 VWFA domain.
  • 结构域Binding to PA occurs through the VWA domain.
  • 细胞定位Cell membrane. Cell projection > lamellipodium membrane. Cell projection > filopodium membrane. At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Anthrax toxin receptor 1 antibody
    • ANTR1_HUMAN antibody
    • Antxr1 antibody
    • ATR antibody
    • Tumor endothelial marker 8 antibody
    see all

Anti-TEM8 antibody [200C1339] 图像

  • Western blot detection of TEM8 in TEM8 transfected cell lysate using ab13798 at 1 µg/ml.
  • Formalin-fixed, paraffin-embedded human colon stained with ab13798 diluted 1:200, detection using peroxidase-conjugated secondary antibody and DAB chromogen.
  • Formalin-fixed, paraffin-embedded human colon stained with ab13798 diluted 1:200, detection using peroxidase-conjugated secondary and DAB chromogen.

Anti-TEM8 antibody [200C1339] (ab13798)参考文献

This product has been referenced in:
  • Sakai Y  et al. Bcl-2 mediated modulation of vascularization in prostate cancer xenografts. Prostate 69:459-70 (2009). WB ; Human . Read more (PubMed: 19107861) »

See 1 Publication for this product

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