Anti-TEM7抗体(ab80754)
Key features and details
- Rabbit polyclonal to TEM7
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Rat
- Isotype: IgG
概述
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产品名称
Anti-TEM7抗体 -
描述
兔多克隆抗体to TEM7 -
宿主
Rabbit -
特异性
ab80754 recognises human Tumour endothelial marker 7 (TEM7), a 55.8 kDa protein belonging to the plexin family. TEM7 is strongly expressed in endothelial cells from colorectal cancer and from primary cancers of the lung, liver, brain, breast and pancreas. High expression of TEM7 is associated with metastasis and poor survival of patients with osteogenic sarcoma. Studies have indicated the existence of least four isoforms of TEM7 which include membrane bound, secreted and intracellular forms. TEM7 is not detectable in endothelial cells from normal tissues. -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Mouse, Rat -
免疫原
16 amino acid synthetic peptide corresponding to an internal sequence of Human TEM7
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阳性对照
- Liver
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab80754于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 56 kDa (predicted molecular weight: 56 kDa).
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IHC-P |
Use a concentration of 2.5 µg/ml. Do not perform antigen retrieval.
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说明 |
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WB
Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 56 kDa (predicted molecular weight: 56 kDa). |
IHC-P
Use a concentration of 2.5 µg/ml. Do not perform antigen retrieval. |
靶标
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功能
Plays a critical role in endothelial cell capillary morphogenesis. -
组织特异性
Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy. -
序列相似性
Belongs to the plexin family. -
翻译后修饰
N-glycosylated. -
细胞定位
Cytoplasm; Secreted and Cell membrane. Cell junction > tight junction. Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells. - Information by UniProt
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数据库链接
- Entrez Gene: 72324 Mouse
- Entrez Gene: 303505 Rat
- SwissProt: Q91ZV7 Mouse
- Unigene: 39617 Mouse
- Unigene: 482750 Mouse
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别名
- DKFZp686F0937 antibody
- FLJ36270 antibody
- FLJ45632 antibody
see all
图片
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Lane 1 : Anti-TEM7 antibody (ab80754) at 0.5 µg/ml
Lane 2 : Anti-TEM7 antibody (ab80754) at 1 µg/ml
All lanes : rat liver lysate.
Predicted band size: 56 kDa
Observed band size: 56 kDa -
ab80754 at 2.5 µg/ml staining TEM7 in mouse liver by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab80754 尚未被引用在任何文献中。