The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用说明Sandwich ELISA and ELISA: Use at a concentration of 10 µg/ml.
WB: 1/500. Detects a band of approximately 75 kDa (predicted molecular weight: 56 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
功能Plays a critical role in endothelial cell capillary morphogenesis.
组织特异性Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy.
序列相似性Belongs to the plexin family.
细胞定位Cytoplasm; Secreted and Cell membrane. Cell junction > tight junction. Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.