Anti-TEF1抗体[EPR5279] (ab109080)


  • 产品名称Anti-TEF1抗体[EPR5279]
    参阅全部 TEF1 一抗
  • 描述
    兔单克隆抗体[EPR5279] to TEF1
  • 经测试应用适用于: WB, Flow Cytmore details
    不适用于: ICC,IHC-P or IP
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues on the C-terminus in Human TEF1.

  • 阳性对照
    • HeLa, A673, A431, BxPC-3, and JAR cell lysates, HeLa cells
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.




Our Abpromise guarantee covers the use of ab109080 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/10000 - 1/50000. Detects a band of approximately 53 kDa (predicted molecular weight: 48 kDa).
Flow Cyt 1/100 - 1/500. ab172730-Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
  • 应用说明Is unsuitable for ICC,IHC-P or IP.
  • 靶标

    • 功能Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
    • 组织特异性Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
    • 疾病相关Defects in TEAD1 are the cause of Sveinsson chorioretinal atrophy (SCRA) [MIM:108985]; also known as atrophia areata (AA) or helicoidal peripapillary chorioretinal degeneration (HPCD). SCRA is characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.
    • 序列相似性Contains 1 TEA DNA-binding domain.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AA antibody
      • Atrophia areata peripapillary chorioretinal degeneration antibody
      • NTEF 1 antibody
      • NTEF-1 antibody
      • NTEF1 antibody
      • Protein GT IIC antibody
      • Protein GT-IIC antibody
      • REF 1 antibody
      • REF1 antibody
      • SV40 transcriptional enhancer factor antibody
      • TCF 13 antibody
      • TCF-13 antibody
      • TCF13 antibody
      • TEA domain family member antibody
      • TEA domain family member 1 (SV40 transcriptional enhancer factor) antibody
      • TEA domain family member 1 antibody
      • TEAD 1 antibody
      • TEAD 1 protein antibody
      • TEAD-1 antibody
      • TEAD1 antibody
      • TEAD1 protein antibody
      • TEAD1_HUMAN antibody
      • TEF 1 antibody
      • Transcription factor 13 (SV40 transcriptional enhancer factor) antibody
      • Transcription factor 13 antibody
      • Transcriptional enhancer factor 1 antibody
      • Transcriptional enhancer factor TEF-1 antibody
      • Transcriptional enhancer factor TEF1 antibody
      see all

    Anti-TEF1 antibody [EPR5279] 图像

    • All lanes : Anti-TEF1 antibody [EPR5279] (ab109080) at 1/10000 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : A673 cell lysate
      Lane 3 : A431 cell lysate
      Lane 4 : BxPC-3 cell lysate
      Lane 5 : JAR cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size : 48 kDa
    • Flow cytometric analysis of permeabilized HeLa cells using ab109080 at a dilution of 1/100.

    Anti-TEF1 antibody [EPR5279] (ab109080)参考文献

    ab109080 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab109080.
    Please use the links above to contact us or submit feedback about this product.