RabMAb

Anti-TEF1抗体[EPR5279] (ab109080)

概述

  • 产品名称Anti-TEF1抗体[EPR5279]
    参阅全部 TEF1 一抗
  • 描述
    兔单克隆抗体[EPR5279] to TEF1
  • 经测试应用适用于: WB, Flow Cytmore details
    不适用于: ICC,IHC-P or IP
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues on the C-terminus in Human TEF1.

  • 阳性对照
    • HeLa, A673, A431, BxPC-3, and JAR cell lysates, HeLa cells
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab109080 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/10000 - 1/50000. Detects a band of approximately 53 kDa (predicted molecular weight: 48 kDa).
Flow Cyt 1/100 - 1/500. ab172730-Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
  • 应用说明Is unsuitable for ICC,IHC-P or IP.
  • 靶标

    • 功能Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
    • 组织特异性Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
    • 疾病相关Defects in TEAD1 are the cause of Sveinsson chorioretinal atrophy (SCRA) [MIM:108985]; also known as atrophia areata (AA) or helicoidal peripapillary chorioretinal degeneration (HPCD). SCRA is characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.
    • 序列相似性Contains 1 TEA DNA-binding domain.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AA antibody
      • Atrophia areata peripapillary chorioretinal degeneration antibody
      • NTEF 1 antibody
      • NTEF-1 antibody
      • NTEF1 antibody
      • Protein GT IIC antibody
      • Protein GT-IIC antibody
      • REF 1 antibody
      • REF1 antibody
      • SV40 transcriptional enhancer factor antibody
      • TCF 13 antibody
      • TCF-13 antibody
      • TCF13 antibody
      • TEA domain family member antibody
      • TEA domain family member 1 (SV40 transcriptional enhancer factor) antibody
      • TEA domain family member 1 antibody
      • TEAD 1 antibody
      • TEAD 1 protein antibody
      • TEAD-1 antibody
      • TEAD1 antibody
      • TEAD1 protein antibody
      • TEAD1_HUMAN antibody
      • TEF 1 antibody
      • Transcription factor 13 (SV40 transcriptional enhancer factor) antibody
      • Transcription factor 13 antibody
      • Transcriptional enhancer factor 1 antibody
      • Transcriptional enhancer factor TEF-1 antibody
      • Transcriptional enhancer factor TEF1 antibody
      see all

    Anti-TEF1 antibody [EPR5279] 图像

    • All lanes : Anti-TEF1 antibody [EPR5279] (ab109080) at 1/10000 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : A673 cell lysate
      Lane 3 : A431 cell lysate
      Lane 4 : BxPC-3 cell lysate
      Lane 5 : JAR cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 48 kDa
    • Flow cytometric analysis of permeabilized HeLa cells using ab109080 at a dilution of 1/100.

    Anti-TEF1 antibody [EPR5279] (ab109080)参考文献

    ab109080 has not yet been referenced specifically in any publications.

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