Anti-TEF1抗体[403C1a] (ab54404)

概述

  • 产品名称Anti-TEF1抗体[403C1a]
    参阅全部 TEF1 一抗
  • 描述
    小鼠单克隆抗体[403C1a] to TEF1
  • 经测试应用适用于: WB, Dot blotmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    TEF1 recombinant fragment (Human)

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液Preservative: 0.05% Sodium Azide
    Constituents: 1% BSA, PBS (8.0mM Sodium phosphate, 3.0mM Potassium chloride, 140mM Sodium chloride, 1.5mM Potassium phosphate, pH 7.4)
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明ab54404 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG depleted (approximately 95%) fetal bovine serum and filtered through a 0.22µm membrane.
  • 克隆单克隆
  • 克隆编号403C1a
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab54404 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Detects a band of approximately 34 kDa (predicted molecular weight: 48 kDa).
Dot blot Use at an assay dependent dilution.

靶标

  • 功能Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
  • 组织特异性Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
  • 疾病相关Defects in TEAD1 are the cause of Sveinsson chorioretinal atrophy (SCRA) [MIM:108985]; also known as atrophia areata (AA) or helicoidal peripapillary chorioretinal degeneration (HPCD). SCRA is characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.
  • 序列相似性Contains 1 TEA DNA-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AA antibody
    • Atrophia areata peripapillary chorioretinal degeneration antibody
    • NTEF 1 antibody
    • NTEF-1 antibody
    • NTEF1 antibody
    • Protein GT IIC antibody
    • Protein GT-IIC antibody
    • REF 1 antibody
    • REF1 antibody
    • SV40 transcriptional enhancer factor antibody
    • TCF 13 antibody
    • TCF-13 antibody
    • TCF13 antibody
    • TEA domain family member antibody
    • TEA domain family member 1 (SV40 transcriptional enhancer factor) antibody
    • TEA domain family member 1 antibody
    • TEAD 1 antibody
    • TEAD 1 protein antibody
    • TEAD-1 antibody
    • TEAD1 antibody
    • TEAD1 protein antibody
    • TEAD1_HUMAN antibody
    • TEF 1 antibody
    • Transcription factor 13 (SV40 transcriptional enhancer factor) antibody
    • Transcription factor 13 antibody
    • Transcriptional enhancer factor 1 antibody
    • Transcriptional enhancer factor TEF-1 antibody
    • Transcriptional enhancer factor TEF1 antibody
    see all

Anti-TEF1 antibody [403C1a] 图像

Anti-TEF1 antibody [403C1a] (ab54404)参考文献

ab54404 has not yet been referenced specifically in any publications.

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