概述

  • 产品名称Anti-TECTA抗体
  • 描述
    小鼠单克隆抗体to TECTA
  • 经测试应用适用于: WB, ELISA, Sandwich ELISAmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment corresponding to amino acids 1981-2081 of Human TECTA (NP_005413), with proprietary tag. Mol wt 37.11 kDa inclusive of tag.

  • 阳性对照
    • Recombinant protein

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液pH: 7.20
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆单克隆
  • 同种型IgG2a
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab118086 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 240 kDa.
ELISA Use at an assay dependent dilution.
Sandwich ELISA Use at an assay dependent concentration.

靶标

  • 功能One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
  • 疾病相关Defects in TECTA are the cause of deafness autosomal dominant type 12 (DFNA12) [MIM:601543]; also known as DFNA8. DFNA12 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
    Defects in TECTA are the cause of deafness autosomal recessive type 21 (DFNB21) [MIM:603629].
  • 序列相似性Contains 1 NIDO domain.
    Contains 3 TIL (trypsin inhibitory-like) domains.
    Contains 1 VWFC domain.
    Contains 4 VWFD domains.
    Contains 1 ZP domain.
  • 结构域Zona pellucida domain may enable to form filaments.
  • 翻译后修饰The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.
  • 细胞定位Cell membrane. Secreted > extracellular space > extracellular matrix. Found in the non-collagenous matrix of the tectorial membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alpha-tectorin antibody
    • DFNA12 antibody
    • DFNA8 antibody
    • DFNB21 antibody
    • OTTHUMP00000195078 antibody
    • TECTA antibody
    • TECTA_HUMAN antibody
    see all

Anti-TECTA antibody 图像

  • Anti-TECTA antibody (ab118086) at 1 µg/ml + Recombinant Protein at 0.1 µg
    Developed using the ECL technique

    Predicted band size : 240 kDa
  • Detection limit for recombinant proprietary tagged TECTA is 0.3 ng/ml as a capture antibody.

Anti-TECTA antibody (ab118086)参考文献

ab118086 has not yet been referenced specifically in any publications.

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