概述

  • 产品名称
  • 描述
    兔多克隆抗体to TECPR1
  • 经测试应用
    适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Aa KLH conjugated synthetic peptide selected from the C-terminal region of Human TECPR1 (NP_056210.1)

  • 阳性对照
    • Mouse brain tissue lysate

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度
    Ammonium Sulphate Precipitation
  • 纯化说明
    Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab91234 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明
    ELISA: 1/1000.
    WB: 1/50 - 1/100. Predicted molecular weight: 130 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.
    • 序列相似性
      Belongs to the TECPR1 family.
      Contains 1 PH domain.
      Contains 9 TECPR repeats.
    • 结构域
      The PH domain mediates the binding to phosphatidylinositol-3-phosphate (PtdIns(3)P). While full-length protein is unable to bind PtdIns(3)P in vitro, it is assumed that the binding to the ATG5-ATG12 conjugate exposes the PH domain, allowing the association with PtdIns(3)P (PubMed:22342342).
    • 细胞定位
      Cytoplasmic vesicle > autophagosome membrane. Lysosome membrane. Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 2210010N04Rik antibody
      • DKFZP434B0335 antibody
      • FLJ23419 antibody
      • FLJ90593 antibody
      • KIAA1358 antibody
      • MGC124730 antibody
      • mKIAA1358 antibody
      • RGD1306873 antibody
      • TCPR1_HUMAN antibody
      • Tecpr1 antibody
      • tectonin beta propeller repeat containing 1 antibody
      • Tectonin beta-propeller repeat-containing protein 1 antibody
      see all

    Anti-TECPR1 antibody 图像

    • Anti-TECPR1 antibody (ab91234) at 1/50 dilution + Mouse brain tissue lysate at 35 µg

      Predicted band size : 130 kDa

    实验方案

    Anti-TECPR1 antibody (ab91234)参考文献

    ab91234 has not yet been referenced specifically in any publications.

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