Anti-TEAD3抗体(ab75192)

概述

  • 产品名称Anti-TEAD3抗体
    参阅全部 TEAD3 一抗
  • 描述
    兔多克隆抗体to TEAD3
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    A synthetic peptide corresponding to a region of Human TEAD3

  • 阳性对照
    • Hela cell lysate.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab75192 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 49 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay: 1/312500.

靶标

  • 功能Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
  • 组织特异性Preferentially expressed in the placenta.
  • 序列相似性Contains 1 TEA DNA-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DTEF 1 antibody
    • DTEF-1 antibody
    • DTEF1 antibody
    • ETFR 1 antibody
    • ETFR1 antibody
    • TEA domain family member 3 antibody
    • TEA domain family member 5 antibody
    • TEAD 3 antibody
    • TEAD-3 antibody
    • Tead3 antibody
    • TEAD3_HUMAN antibody
    • TEAD5 antibody
    • TEF 5 antibody
    • TEF5 antibody
    • Transcriptional enhancer factor 5 antibody
    • Transcriptional enhancer factor TEF 5 (DTEF 1) antibody
    • Transcriptional enhancer factor TEF 5 antibody
    • Transcriptional enhancer factor TEF-5 antibody
    see all

Anti-TEAD3 antibody 图像

  • Anti-TEAD3 antibody (ab75192) at 1 µg/ml (in 5% skim milk / PBS buffer) + Hela cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 49 kDa
    Observed band size : 49 kDa

Anti-TEAD3 antibody (ab75192)参考文献

ab75192 has not yet been referenced specifically in any publications.

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Read More
Application Western blot
Sample Mouse Cell lysate - whole cell (CCE S 103 mouse stem cells)
Loading amount 50 µg
Specification CCE S 103 mouse stem cells
Gel Running Conditions Reduced Denaturing
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 20°C
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提交于 Jun 04 2012

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"