概述

  • 产品名称Anti-TDRD1抗体
    参阅全部 TDRD1 一抗
  • 描述
    兔多克隆抗体to TDRD1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 950 - 1050 of Mouse TDRD1.

  • 阳性对照
    • This antibody gave a positive signal in Mouse testis tissue lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituent: PBS
    Note: Batches of this product that have a concentration < 1mg/ml may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help.
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab104812 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 148 kDa (predicted molecular weight: 130 kDa).

靶标

  • 功能Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins.
  • 组织特异性Testis and ovary specific. Also expressed in several cancers.
  • 序列相似性Belongs to the TDRD1 family.
    Contains 1 MYND-type zinc finger.
    Contains 4 Tudor domains.
  • 结构域Tudor domains 2 and 3 have higher affinity for arginine-methylated peptides, tudor domain 1 is a poor binder due to an impaired aromatic cage.
  • 细胞定位Cytoplasm. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body (By similarity).
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cancer/testis antigen 41.1 antibody
    • CT41.1 antibody
    • FLJ21082 antibody
    • MTR 1 antibody
    • TDRD 1 antibody
    • tdrd1 antibody
    • TDRD1_HUMAN antibody
    • Tudor domain containing 1 antibody
    • Tudor domain containing protein 1 antibody
    • Tudor domain-containing protein 1 antibody
    see all

Anti-TDRD1 antibody 图像

  • Anti-TDRD1 antibody (ab104812) at 1 µg/ml + Testis (Mouse) Tissue Lysate at 10 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 130 kDa
    Observed band size : 148 kDa (why is the actual band size different from the predicted?)


    Exposure time : 16 minutes

Anti-TDRD1 antibody (ab104812)参考文献

ab104812 has not yet been referenced specifically in any publications.

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